Snake venom α-neurotoxins and other 'three-finger' proteins

被引：258

作者：

Tsetlin, V ^{[1
]}

机构：

[1] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117871, Russia

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 1999年 / 264卷 / 02期

关键词：

acetylcholine receptors; binding surfaces; neurotoxins; primary structure; spatial structure; 'three-finger' proteins;

D O I：

10.1046/j.1432-1327.1999.00623.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The review is mainly devoted to snake venom alpha-neurotoxins which target different muscle-type and neuronal nicotinic acetylcholine receptors. The primary and spatial structures of other snake venom proteins as well as mammalian proteins of the Ly-6 family, which structurally resemble the 'three-finger' snake proteins, are also briefly discussed. The main emphasis is placed on recent data characterizing the alpha-neurotoxin interactions with nicotinic acetylcholine receptors.

引用

页码：281 / 286

页数：6

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