Oxygenation and metabolic status of KHT tumors as measured simultaneously by F-19 magnetic resonance imaging and P-31 magnetic resonance spectroscopy

被引:24
作者
Baldwin, NJ
Ng, TC
机构
[1] Magnetic Resonance Research Center, Division of Radiology, Cleveland Clinic Foundation, Cleveland, OH
[2] Magnetic Resonance Research Center, Division of Radiology, L-10, Cleveland Clinic Foundation, Cleveland
关键词
pO(2); tumor metabolism; F-19 MRI(31)P MRS and KHT tumors;
D O I
10.1016/0730-725X(96)00049-5
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
To evaluate the relationship between the partial pressure of oxygen (pO(2)) and the energy-related phosphorous metabolites in individual KHT murine sarcomas more clearly, the spatial distributions of pO(2) were obtained simultaneously with P-31 magnetic resonance spectra, and repeatedly as a function of growth. The pO(2). maps, derived from serial images of the spin-lattice relaxation times of sequestered perfluorocarbon emulsions, were heterogeneous spatially, which is characteristic of solid tumors. Collectively, the median pO(2) of the seven KHT tumors of mass varying from 0.2 to 1.8 g decreased from 60 to 0 mmHg, but it increased in one of five tumors which were followed in the growth study. The pH(MRS) and the high-energy ratio of phosphocreatine + nucleoside triphosphates to total observed phosphorous (TP) dropped on average as a function of tumor growth, while the low energy ratio of P-i to TP increased. Also, for the tumors as a whole, the pH and high-energy ratio increased with increasing median pO(2) while the low energy ratio decreased, but the P-31 values of some tumors did not follow this general trend. These individual variations suggest the need for simultaneous and repeated measurements of phosphorous metabolites and oxygen tension for complete information regarding the tumor status in experimental studies and therapeutic procedures in humans.
引用
收藏
页码:541 / 551
页数:11
相关论文
共 38 条
[1]  
BALDWIN NJ, 1992, 11TH P SMRM BERL, P3501
[2]   RAPID TISSUE OXYGEN-TENSION MAPPING USING F-19 INVERSION-RECOVERY ECHO-PLANAR IMAGING OF PERFLUORO-15-CROWN-5-ETHER [J].
DARDZINSKI, BJ ;
SOTAK, CH .
MAGNETIC RESONANCE IN MEDICINE, 1994, 32 (01) :88-97
[3]   CONSIDERATION OF RANDOM ERRORS IN THE QUANTITATIVE IMAGING OF NMR RELAXATION [J].
DORAN, SJ ;
ATTARD, JJ ;
ROBERTS, TPL ;
CARPENTER, TA ;
HALL, LD .
JOURNAL OF MAGNETIC RESONANCE, 1992, 100 (01) :101-122
[4]   NMR-STUDY OF INVIVO RIF-1 TUMORS - ANALYSIS OF PERCHLORIC-ACID EXTRACTS AND IDENTIFICATION OF H-1-RESONANCES, P-31-RESONANCES AND C-13-RESONANCES [J].
EVANOCHKO, WT ;
SAKAI, TT ;
NG, TC ;
KRISHNA, NR ;
KIM, HD ;
ZEIDLER, RB ;
GHANTA, VK ;
BROCKMAN, RW ;
SCHIFFER, LM ;
BRAUNSCHWEIGER, PG ;
GLICKSON, JD .
BIOCHIMICA ET BIOPHYSICA ACTA, 1984, 805 (01) :104-116
[5]  
EVELHOCH JL, 1986, RADIAT RES, V106, P122, DOI 10.2307/3576567
[6]   INVIVO MEASUREMENTS OF VASCULAR OXYGEN-TENSION IN TUMORS USING MRI OF A FLUORINATED BLOOD SUBSTITUTE [J].
FISHMAN, JE ;
JOSEPH, PM ;
CARVLIN, MJ ;
SAADIELMANDJRA, M ;
MUKHERJI, B ;
SLOVITER, HA .
INVESTIGATIVE RADIOLOGY, 1989, 24 (01) :65-71
[7]   OXYGEN DISTRIBUTION IN SQUAMOUS-CELL CARCINOMA METASTASES AND ITS RELATIONSHIP TO OUTCOME OF RADIATION-THERAPY [J].
GATENBY, RA ;
KESSLER, HB ;
ROSENBLUM, JS ;
COIA, LR ;
MOLDOFSKY, PJ ;
HARTZ, WH ;
BRODER, GJ .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1988, 14 (05) :831-838
[8]   ENERGY STATUS AND RADIOBIOLOGICAL HYPOXIA AT SPECIFIED OXYGEN CONCENTRATIONS [J].
GERWECK, LE ;
SENEVIRATNE, T ;
GERWECK, KK .
RADIATION RESEARCH, 1993, 135 (01) :69-74
[9]  
GERWECK LE, 1992, 40 ANN M RAD RES SOC
[10]   THE CONCENTRATION OF OXYGEN DISSOLVED IN TISSUES AT THE TIME OF IRRADIATION AS A FACTOR IN RADIOTHERAPY [J].
GRAY, LH ;
CONGER, AD ;
EBERT, M ;
HORNSEY, S ;
SCOTT, OCA .
BRITISH JOURNAL OF RADIOLOGY, 1953, 26 (312) :638-648