EEG Oscillatory Phase-Dependent Markers of Corticospinal Excitability in the Resting Brain

被引:61
作者
Berger, Barbara [1 ]
Minarik, Tamas [1 ]
Liuzzi, Gianpiero [2 ]
Hummel, Friedhelm C. [3 ]
Sauseng, Paul [1 ]
机构
[1] Univ Surrey, Sch Psychol, Brain & Behav Res Grp, Guildford GU2 7XH, Surrey, England
[2] Univ Spital Zurich, Neurol Clin, CH-8091 Zurich, Switzerland
[3] Univ Med Ctr Hamburg Eppendorf, Dept Neurol, Brain Imaging & Neurostimulat Lab, D-20246 Hamburg, Germany
基金
奥地利科学基金会;
关键词
ALPHA; STIMULATION;
D O I
10.1155/2014/936096
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 [微生物学]; 090105 [作物生产系统与生态工程];
摘要
Functional meaning of oscillatory brain activity in various frequency bands in the human electroencephalogram (EEG) is increasingly researched. While most research focuses on event-related changes of brain activity in response to external events there is also increasing interest in internal brain states influencing information processing. Several studies suggest amplitude changes of EEG oscillatory activity selectively influencing cortical excitability, and more recently it was shown that phase of EEG activity (instantaneous phase) conveys additional meaning. Here we review this field with many conflicting findings and further investigate whether corticospinal excitability in the resting brain is dependent on a specific spontaneously occurring brain state reflected by amplitude and instantaneous phase of EEG oscillations. We applied single pulse transcranial magnetic stimulation (TMS) over the left sensorimotor cortex, while simultaneously recording ongoing oscillatory activity with EEG. Results indicate that brain oscillations reflect rapid, spontaneous fluctuations of cortical excitability. Instantaneous phase but not amplitude of oscillations at various frequency bands at stimulation site at the time of TMS-pulse is indicative for brain states associated with different levels of excitability (defined by size of the elicited motor evoked potential). These results are further evidence that ongoing brain oscillations directly influence neural excitability which puts further emphasis on their role in orchestrating neuronal firing in the brain.
引用
收藏
页数:8
相关论文
共 23 条
[1]
CircStat: A MATLAB Toolbox for Circular Statistics [J].
Berens, Philipp .
JOURNAL OF STATISTICAL SOFTWARE, 2009, 31 (10) :1-21
[2]
The Phase of Ongoing EEG Oscillations Predicts Visual Perception [J].
Busch, Niko A. ;
Dubois, Julien ;
VanRullen, Rufin .
JOURNAL OF NEUROSCIENCE, 2009, 29 (24) :7869-7876
[3]
Neuronal oscillations in cortical networks [J].
Buzsáki, G ;
Draguhn, A .
SCIENCE, 2004, 304 (5679) :1926-1929
[4]
RELATIONSHIP BETWEEN REACTION TIME AND ELECTROENCEPHALOGRAPHIC ALPHA-PHASE [J].
CALLAWAY, E ;
YEAGER, CL .
SCIENCE, 1960, 132 (3441) :1765-1766
[5]
Beta-band oscillations - signalling the status quo? [J].
Engel, Andreas K. ;
Fries, Pascal .
CURRENT OPINION IN NEUROBIOLOGY, 2010, 20 (02) :156-165
[6]
Alpha phase synchronization predicts P1 and N1 latency and amplitude size [J].
Gruber, WR ;
Klimesch, W ;
Sauseng, P ;
Doppelmayr, M .
CEREBRAL CORTEX, 2005, 15 (04) :371-377
[7]
Prestimulus oscillations predict between and within subjects [J].
Hanslmayr, Simon ;
Aslan, Alp ;
Staudigl, Tobias ;
Klimesch, Wolfgang ;
Herrmann, Christoph S. ;
Baeuml, Karl-Heinz .
NEUROIMAGE, 2007, 37 (04) :1465-1473
[9]
LINDSLEY D B, 1952, Res Publ Assoc Res Nerv Ment Dis, V30, P174
[10]
EEG oscillations and magnetically evoked motor potentials reflect motor system excitability in overlapping neuronal populations [J].
Maki, Hanna ;
Ilmoniemi, Risto J. .
CLINICAL NEUROPHYSIOLOGY, 2010, 121 (04) :492-501