Protection of a polysaccharide from Salvia miltiorrhiza, a Chinese medicinal herb, against immunological liver injury in mice

被引：111

作者：

Song, Yu-Hong ^{[2
]}

Liu, Qiang ^{[1
]}

Lv, Zhi-Ping ^{[1
]}

Chen, Yu-Yao ^{[1
]}

Zhou, Ying-Chun ^{[2
]}

Sun, Xue-Gang ^{[1
]}

机构：

[1] So Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Guangdong, Peoples R China

[2] So Med Univ, Nanfang Hosp, Dept Tradit Chinese Med, Guangzhou 510515, Guangdong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2008年 / 43卷 / 02期

关键词：

Salvia miltiorrhiza; polysaccharides; immunological liver injury;

D O I：

10.1016/j.ijbiomac.2008.04.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

This study was designed to evaluate the hepatoprotective effects of S. miltiorrhiza polysaccharides (SMPS) in immunological liver injury induced by Bacille-Calmette-Guerin (BCG) and lipopolysaccharide (LPS) in mice. SMPS effectively improved the liver index, spleen index and thymus index, reduced the serum levels of alanine aminotransferase, aspartate aminotransferase and nitric oxide, and restored liver homogenate contents of tumor necrosis factor-alpha and interleukin-1 beta. The histopathological analysis suggested that SMPS reduced the degree of liver injury. The results suggest that SMPS play a protective role against immunological liver injury, which may have important implications for our understanding on the immunoregulatory mechanisms of polysaccharides. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：170 / 175

页数：6

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