Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions

被引:240
作者
Cadet, Jean [1 ]
Mouret, Stephane [1 ]
Ravanat, Jean-Luc [1 ]
Douki, Thierry [1 ]
机构
[1] CEA Grenoble, Inst Nanosci & Cryogenie, Lab Les Acides Nucl, SCIB UMR E CEA UJF 3, Grenoble, France
关键词
CYCLOBUTANE PYRIMIDINE DIMERS; HUMAN SKIN CELLS; OXIDATIVELY GENERATED DAMAGE; INTERSTRAND CROSS-LINKS; THYMINE-THYMINE ADDUCT; ONE-ELECTRON OXIDATION; NUCLEIC-ACID STRUCTURE; WAVELENGTH DEPENDENCE; TITANIUM-DIOXIDE; ULTRAVIOLET-RADIATION;
D O I
10.1111/j.1751-1097.2012.01200.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The survey focuses on recent aspects of photochemical reactions to cellular DNA that are implicated through the predominant formation of mostly bipyrimidine photoproducts in deleterious effects of human exposure to sunlight. Recent developments in analytical methods have allowed accurate and quantitative measurements of the main DNA photoproducts in cells and human skin. Highly mutagenic CC and CT bipyrimidine photoproducts, including cyclobutane pyrimidine dimers and pyrimidine (6-4) pyrimidone photoproducts (6-4PPs) are generated in low yields with respect to TT and TC photoproducts. Another striking finding deals with the formation of Dewar valence isomers, the third class of bipyrimidine photoproducts that is accounted for by UVA-mediated isomerization of initially UVB generated 6-4PPs. Cyclobutadithymine (T <> T) has been unambiguously shown to be involved in the genotoxicity of UVA radiation. Thus, T <> T is formed in UVA-irradiated cellular DNA according to a direct excitation mechanism with a higher efficiency than oxidatively generated DNA damage that arises mostly through the Type II photosensitization mechanism. C <> C and C <> T are repaired at rates intermediate between those of T <> T and 6-4TT. Evidence has been also provided for the occurrence of photosensitized reactions mediated by exogenous agents that act either in an independent way or through photodynamic effects.
引用
收藏
页码:1048 / 1065
页数:18
相关论文
共 235 条
[1]   Induction of oxidative cell damage by photo-treatment with zinc N-methylpyridylporphyrin [J].
Al-Mutairi, Dalal A. ;
Craik, James D. ;
Batinic-Haberle, Ines ;
Benov, Ludmil T. .
FREE RADICAL RESEARCH, 2007, 41 (01) :89-96
[2]  
Angelov D, 2003, PHOTOCHEM PHOTOBIOL, V77, P592, DOI 10.1562/0031-8655(2003)077<0592:SSOTNP>2.0.CO
[3]  
2
[4]  
[Anonymous], 2012, ENCYCL RADICALS CHEM, DOI DOI 10.1002/9781119953678.RAD038
[5]  
Anselmino C, 1995, PHOTOCHEM PHOTOBIOL, V62, P997
[6]   UV-Induced TA Photoproducts: Formation and Hydrolysis in Double-Stranded DNA [J].
Asgatay, Saadia ;
Martinez, Agathe ;
Coantic-Castex, Stephanie ;
Harakat, Dominique ;
Philippe, Coralie ;
Douki, Thierry ;
Clivio, Pascale .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (30) :10260-10261
[7]   UVA photosensitization of thiopurines and skin cancer in organ transplant recipients [J].
Attard, Natalie R. ;
Karran, Peter .
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 2012, 11 (01) :62-68
[8]   Base Pairing Enhances Fluorescence and Favors Cyclobutane Dimer Formation Induced upon Absorption of UVA Radiation by DNA [J].
Banyasz, Akos ;
Vaya, Ignacio ;
Changenet-Barret, Pascale ;
Gustavsson, Thomas ;
Douki, Thierry ;
Markovitsi, Dimitra .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (14) :5163-5165
[9]   Type II guanine oxidation photoinduced by the antibacterial fluoroquinolone rufloxacin in isolated DNA and in 2′-deoxyguanosine [J].
Belvedere, A ;
Boscá, F ;
Catalfo, A ;
Cuquerella, MC ;
de Guidi, G ;
Miranda, MA .
CHEMICAL RESEARCH IN TOXICOLOGY, 2002, 15 (09) :1142-1149
[10]   DNA lesions induced by UV A1 and B radiation in human cells:: Comparative analyses in the overall genome and in the p53 tumor suppressor gene [J].
Besaratinia, A ;
Synold, TW ;
Chen, HH ;
Chang, C ;
Xi, BX ;
Riggs, AD ;
Pfeifer, GP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (29) :10058-10063