Lipophilic derivatives of cyclam as new inhibitors of tumor cell growth

被引：64

作者：

Sibert, JW

Cory, AH

Cory, JG

机构：

[1] Univ Texas, Dept Chem, Richardson, TX 75083 USA

[2] E Carolina Univ, Brody Sch Med, Dept Biochem, Greenville, NC 27858 USA

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 02期

关键词：

D O I：

10.1039/b107899m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two new lipophilic tetraazamacrocycles were prepared and, in contrast to non-lipophilic analogs, found to be potent inhibitors of tumor cell growth in vitro with IC50 values below 10 micromolar.

引用

页码：154 / 155

页数：2

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