From Animalcules to an Ecosystem: Application of Ecological Concepts to the Human Microbiome

被引：68

作者：

Fierer, Noah ^{[1
,2
]}

Ferrenberg, Scott ^{[1
]}

Flores, Gilberto E. ^{[2
]}

Gonzalez, Antonio ^{[3
]}

Kueneman, Jordan ^{[1
]}

Legg, Teresa ^{[1
]}

Lynch, Ryan C. ^{[1
]}

McDonald, Daniel ^{[4
]}

Mihaljevic, Joseph R. ^{[1
]}

O'Neill, Sean P. ^{[1
,5
]}

Rhodes, Matthew E. ^{[1
]}

Song, Se Jin ^{[1
]}

Walters, William A. ^{[6
]}

机构：

[1] Univ Colorado, Dept Ecol & Evolutionary Biol, Boulder, CO 80309 USA

[2] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA

[3] Univ Colorado, Dept Comp Sci, Boulder, CO 80309 USA

[4] Univ Colorado, Biofrontiers Inst, Boulder, CO 80309 USA

[5] Univ Colorado, Inst Arctic & Alpine Res, Boulder, CO 80309 USA

[6] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA

来源：

ANNUAL REVIEW OF ECOLOGY, EVOLUTION, AND SYSTEMATICS, VOL 43 | 2012年 / 43卷

关键词：

bacterial diversity; host-associated bacterial communities; microbial diversity; microbial ecology; DISTAL GUT MICROBIOTA; GASTROINTESTINAL MICROBIOTA; METAGENOMIC ANALYSIS; VAGINAL MICROBIOME; MOLECULAR ANALYSIS; BIOFILM FORMATION; FECAL MICROBIOTA; BETA DIVERSITY; BODY HABITATS; BIODIVERSITY;

D O I：

10.1146/annurev-ecolsys-110411-160307

中图分类号：

Q14 [生态学（生物生态学）];

学科分类号：

071012 ; 0713 ;

摘要：

The human body is inhabited by billions of microbial cells and these microbial symbionts play critical roles in human health. Human-associated microbial communities are diverse, and the structure of these communities is variable across body habitats, through time, and between individuals. We can apply concepts developed by plant and animal ecologists to better understand and predict the spatial and temporal patterns in these communities. Due to methodological limitations and the largely unknown natural history of most microbial taxa, this integration of ecology into research on the human microbiome is still in its infancy. However, such integration will yield a deeper understanding of the role of the microbiome in human health and an improved ability to test ecological concepts that are more difficult to test in plant and animal systems.

引用

页码：137 / 155

页数：19

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