Lineage fate and intense debate: myths, models and mechanisms of CD4-versus CD8-lineage choice

被引：348

作者：

Singer, Alfred ^{[1
]}

Adoro, Stanley ^{[1
]}

Park, Jung-Hyun ^{[1
]}

机构：

[1] NCI, Expt Immunol Branch, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2008年 / 8卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri2416

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Following successful gene rearrangement at alpha beta T-cell receptor (TCR) loci, developing thymocytes express both CD4 and CD8 co-receptors and undergo a life-or-death selection event, which is known as positive selection, to identify cells that express TCRs with potentially useful ligand specificities. Positively selected thymocytes must then differentiate into either CD4(+) helper T cells or CD8(+) cytotoxic T cells, a crucial decision known as CD4/CD8-lineage choice. In this Review, we summarize recent advances in our understanding of the cellular and molecular events involved in lineage-fate decision and discuss them in the context of the major models of CD4/CD8-lineage choice.

引用

页码：788 / 801

页数：14

共 118 条

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