Evidence for uncoupling of oxygen and glucose utilization during neuronal activation in rat striatum

被引：60

作者：

Lowry, JP ^{[1
]}

Fillenz, M ^{[1
]}

机构：

[1] UNIV OXFORD,PHYSIOL LAB,OXFORD OX1 3PT,ENGLAND

来源：

JOURNAL OF PHYSIOLOGY-LONDON | 1997年 / 498卷 / 02期

关键词：

D O I：

10.1113/jphysiol.1997.sp021875

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

1. Changes in regional cerebral blood flow (rCBF), tissue oxygen and extracellular glucose were measured during neuronal activation, using implanted electrodes in the striatum of freely moving rats. 2. There was a parallel increase in rCBF and oxygen in response to neuronal activation. 3. During the neuronal activation there was a decrease in extracellular glucose; following neuronal activation there was a slow rise in extracellular glucose which took 30 min to return to basal levels. 4. The implications of the different time courses of these changes are discussed.

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页码：497 / 501

页数：5

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