The first enantioselective synthesis of the amino acid, (2S,3S,4R)-γ-hydroxyisoleucine using a palladium(II) catalysed 3,3-sigmatropic rearrangement

被引：22

作者：

Jamieson, AG

Sutherland, A

Willis, CL

机构：

[1] Univ Glasgow, Dept Chem, Glasgow G12 8QQ, Lanark, Scotland

[2] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2004年 / 2卷 / 06期

关键词：

D O I：

10.1039/b401076k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthetic route towards the synthesis of (2S, 3S,4R)- gamma-hydroxyisoleucine, the amino acid component of the natural product, funebrine has been developed using as the key step, a palladium(II) catalysed 3,3-sigmatropic rearrangement to create the (2S)-stereogenic centre.

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页码：808 / 809

页数：2

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