Peptide-amphiphile nanofibers: A versatile scaffold for the preparation of self-assembling materials

被引:1015
作者
Hartgerink, JD
Beniash, E
Stupp, SI
机构
[1] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA
[2] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA
[3] Northwestern Univ, Sch Med, Evanston, IL 60208 USA
关键词
D O I
10.1073/pnas.072699999
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Twelve derivatives of peptide-amphiphile molecules, designed to self-assemble into nanofibers, are described. The scope of amino acid selection and alkyl tail modification in the peptide-amphiphile molecules are investigated, yielding nanofibers varying in morphology, surface chemistry, and potential bioactivity. The results demonstrate the chemically versatile nature of this supramolecular system and its high potential for manufacturing nanomaterials. In addition, three different modes of self-assembly resulting in nanofibers are described, including pH control, divalent ion induction, and concentration.
引用
收藏
页码:5133 / 5138
页数:6
相关论文
共 52 条
  • [1] PRINCIPLES THAT GOVERN FOLDING OF PROTEIN CHAINS
    ANFINSEN, CB
    [J]. SCIENCE, 1973, 181 (4096) : 223 - 230
  • [2] SYNTHETIC LIPIDATION OF PEPTIDES AND AMINO-ACIDS - MONOLAYER STRUCTURE AND PROPERTIES
    BERNDT, P
    FIELDS, GB
    TIRRELL, M
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (37) : 9515 - 9522
  • [3] Supramolecular polymers
    Brunsveld, L
    Folmer, BJB
    Meijer, EW
    [J]. MRS BULLETIN, 2000, 25 (04) : 49 - 53
  • [4] Clark TD, 1999, CHEM-EUR J, V5, P782, DOI 10.1002/(SICI)1521-3765(19990201)5:2<782::AID-CHEM782>3.0.CO
  • [5] 2-A
  • [6] GELATION - A REVIEW
    DJABOUROV, M
    [J]. POLYMER INTERNATIONAL, 1991, 25 (03) : 135 - 143
  • [7] Self-assembly of disk-shaped molecules to coiled-coil aggregates with tunable helicity
    Engelkamp, H
    Middelbeek, S
    Nolte, RJM
    [J]. SCIENCE, 1999, 284 (5415) : 785 - 788
  • [8] Fields GB, 1998, BIOPOLYMERS, V47, P143, DOI 10.1002/(SICI)1097-0282(1998)47:2<143::AID-BIP3>3.0.CO
  • [9] 2-U
  • [10] SELF-ASSEMBLING ORGANIC NANOTUBES BASED ON A CYCLIC PEPTIDE ARCHITECTURE
    GHADIRI, MR
    GRANJA, JR
    MILLIGAN, RA
    MCREE, DE
    KHAZANOVICH, N
    [J]. NATURE, 1993, 366 (6453) : 324 - 327