Body mass index is a stronger predictor of alanine aminotransaminase levels than alcohol consumption

被引:48
作者
Adams, Leon A. [1 ]
Knuiman, Matthew W. [2 ]
Divitini, Mark L. [2 ]
Olynyk, John K. [1 ]
机构
[1] Univ Western Australia, Fremantle Hosp Campus, Sch Med & Pharmacol, Fremantle, WA, Australia
[2] Univ Western Australia, Sch Populat Hlth, Crawley, WA, Australia
关键词
alcohol; aminotransaminases; body mass index; non-alcoholic fatty liver disease;
D O I
10.1111/j.1440-1746.2008.05451.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background and Aims: The relative effects of obesity compared to alcohol on liver injury are uncertain. We examined their effects on alanine aminotransferase (ALT) and gamma glutamyltransferase (GGT) levels in a population-based cohort. Methods: Adult residents (2610: 1326 males, 1284 females) from Busselton, Australia, participated in a cross-sectional survey determining alcohol intake as determined by a validated questionnaire, anthropometric measurements and serum analysis. Alcohol consumption was classified as never, light (< 140 g/week), moderate (140-420 g/week) or heavy (> 420 g/week). Results: The majority of subjects were either overweight (41%) or obese (17%). A minority of subjects were moderate (25%) or heavy drinkers (4%). Body mass index (BMI) and waist circumference were strongly associated with ALT and GGT (P < 0.0001 for all tests). Alcohol consumption was modestly associated with ALT in females (P = 0.01) but not in males (P = 0.9). In contrast, GGT was significantly associated with alcohol in both genders (P < 0.0005). The risk of an elevated ALT was seven-fold higher with obesity but only two-fold higher with moderate or heavy alcohol use. Obesity accounted for half of all elevated ALT levels in the cohort, whereas alcohol excess was responsible for less than 10%. No synergistic effect was observed between BMI or waist circumference and alcohol on ALT or GGT (P > 0.2 for all tests). Conclusions: Excess weight is more common than excessive alcohol consumption in the community and confers a greater risk of elevated aminotransaminase levels.
引用
收藏
页码:1089 / 1093
页数:5
相关论文
共 25 条
[1]   The natural history of nonalcoholic fatty liver disease: A population-based cohort study [J].
Adams, LA ;
Lymp, JF ;
St Sauver, J ;
Sanderson, SO ;
Lindor, KD ;
Feldstein, A ;
Angulo, P .
GASTROENTEROLOGY, 2005, 129 (01) :113-121
[2]   Prevalence of and risk factors for hepatic steatosis in northern Italy [J].
Bellentani, S ;
Saccoccio, G ;
Masutti, F ;
Crocè, LS ;
Brandi, G ;
Sasso, F ;
Cristanini, G ;
Tiribelli, C .
ANNALS OF INTERNAL MEDICINE, 2000, 132 (02) :112-117
[3]   Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity [J].
Browning, JD ;
Szczepaniak, LS ;
Dobbins, R ;
Nuremberg, P ;
Horton, JD ;
Cohen, JC ;
Grundy, SM ;
Hobbs, HH .
HEPATOLOGY, 2004, 40 (06) :1387-1395
[4]   Molecular mediators of hepatic steatosis and liver injury [J].
Browning, JD ;
Horton, JD .
JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (02) :147-152
[5]   Carbohydrate-deficient transferrin as a marker of change in alcohol intake in men drinking 20 to 60 g of alcohol per day [J].
Burke, V ;
Puddey, IB ;
Rakic, V ;
Swanson, NR ;
Dimmitt, SB ;
Beilin, LJ ;
Ching, S ;
Beilby, JP .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1998, 22 (09) :1973-1980
[6]  
Clark JM, 2003, AM J GASTROENTEROL, V98, P960, DOI [10.1016/S0002-9270(03)00265-X, 10.1111/j.1572-0241.2003.07486.x]
[7]   Obesity and alcoholic liver disease [J].
Diehl, AM .
ALCOHOL, 2004, 34 (01) :81-87
[8]   Prevalence and trends in obesity among US adults, 1999-2000 [J].
Flegal, KM ;
Carroll, MD ;
Ogden, CL ;
Johnson, CL .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (14) :1723-1727
[9]  
FLEGAL KM, 2005, OBSTET GYNECOL SURV, V60, P593
[10]   Effect of weight reduction on liver histology and biochemistry in patients with chronic hepatitis C [J].
Hickman, IJ ;
Clouston, AD ;
Macdonald, GA ;
Purdie, DM ;
Prins, JB ;
Ash, S ;
Jonsson, JR ;
Powell, EE .
GUT, 2002, 51 (01) :89-94