VEGF and Podocytes in Diabetic Nephropathy

被引：206

作者：

Tufro, Alda ^{[1
]}

Veron, Delma ^{[1
]}

机构：

[1] Yale Univ, Dept Pediat, Nephrol Sect, Sch Med, New Haven, CT 06520 USA

来源：

SEMINARS IN NEPHROLOGY | 2012年 / 32卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Diabetes mellitus; diabetic nephropathy/complications; VEGF-A; endothelial nitric oxide synthase (eNOS); VEGF receptor 2 (VEGFR2); reactive oxygen species (ROS); ENDOTHELIAL-GROWTH-FACTOR; VASCULAR-PERMEABILITY FACTOR; NEPHROTIC-RANGE ALBUMINURIA; INDUCIBLE FACTOR 1-ALPHA; RENAL-DISEASE; EARLY-STAGE; IN-VITRO; EXPRESSION; RECEPTOR; ANGIOGENESIS;

D O I：

10.1016/j.semnephrol.2012.06.010

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

100201 [内科学]; 100221 [泌尿外科学];

摘要：

Vascular endothelial growth factor-A (VEGF-A) is a protein secreted by podocytes that is necessary for survival of endothelial cells, podocytes, and mesangial cells. VEGF-A regulates slit-diaphragm signaling and podocyte shape via VEGF-receptor 2-nephrin-nck-actin interactions. Chronic hyperglycemia-induced excess podocyte VEGF-A and low endothelial nitric oxide drive the development and the progression of diabetic nephropathy. The abnormal cross-talk between VEGF-A and nitric oxide pathways is fueled by the diabetic milieu, resulting in increased oxidative stress. Recent findings on these pathogenic molecular mechanisms provide new potential targets for therapy for diabetic renal disease. Semin Nephrol 32:385-393 (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：385 / 393

页数：9

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