Nerve growth factor acts via retinoic acid synthesis to stimulate neurite outgrowth

被引：114

作者：

Corcoran, J ^{[1
]}

Maden, M ^{[1
]}

机构：

[1] Univ London Kings Coll, Randall Inst, Dev Biol Res Ctr, London WC2B 5RL, England

来源：

NATURE NEUROSCIENCE | 1999年 / 2卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/7214

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nerve growth factor (NGF) stimulates neurite outgrowth from cultured adult dorsal root ganglia (DRG)1, and the vitamin A derivative all-trans-retinoic acid (tRA) induces neurite outgrowth from various embryonic sources, including DRG2,3. Are such similarities in effects of NGF and tRA because they are both components of the same genetic cascade leading to neurite outgrowth? tRA upregulates low-and high-affinity NGF receptors3,4 and induces the transcription of NGF itself5, suggesting that tRA may be upstream of NGF, but we show the converse, namely, that NGF is upstream of tRA.

引用

页码：307 / 308

页数：2

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