Total glucosides of paeony inhibits Th1/Th17 cells via decreasing dendritic cells activation in rheumatoid arthritis

被引：109

作者：

Lin, Jinpiao ^{[1
]}

Xiao, Lianbo ^{[2
]}

Ouyang, Guilin ^{[2
]}

Shen, Yu ^{[2
]}

Huo, Rongfen ^{[1
]}

Zhou, Zhou ^{[1
]}

Sun, Yue ^{[1
]}

Zhu, Xianjin ^{[1
]}

Zhang, Jie ^{[1
]}

Shen, Baihua ^{[1
]}

Li, Ningli ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Immunol, Inst Med Sci, Shanghai 200025, Peoples R China

[2] Guanghua Rheumatol Hosp, Shanghai, Peoples R China

来源：

CELLULAR IMMUNOLOGY | 2012年 / 280卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Total glucosides of paeony; Th1/Th17; cells; Dendritic cells; Maturation; Rheumatoid arthritis; COLLAGEN-INDUCED ARTHRITIS; TH17; CELLS; ADJUVANT ARTHRITIS; AUTOIMMUNE-DISEASES; T-CELLS; IN-VIVO; MECHANISMS; DIFFERENTIATION; SYNOVIOCYTES; CYTOKINES;

D O I：

10.1016/j.cellimm.2012.12.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Total glucoside of paeony (TGP), an active compound extracted from paeony root, has been used in therapy for rheumatoid arthritis (RA). Th1 and Th17 cells are now believed to play crucial roles in the lesions of RA. However, the molecular mechanism of TGP in inhibition of Th1 and Th17 cells remains unclear. In this study, we found that TGP treatment significantly decreased percentage and number of Th1 and Th17 cells in collagen induced arthritis (CIA) mice. Consistently, treatment with TGP decreased expression of T-bet and ROR gamma t as well as phosphorylation of STAT1 and STAT3. In particular, TGP treatment inhibited dendritic cells (DCs) maturation and reduced production of IL-12 and IL-6. Moreover, TGP-treatment RA patients showed shank population of matured DCs and IFN-gamma-, IL-17-producing cells. Taken together, our results demonstrated that TGP inhibited maturation and activation of DCs, which led to impaired Th1 and Th17 differentiation in vivo. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：156 / 163

页数：8

共 41 条

[1]

Adorini L, 1997, CHEM IMMUNOL, V68, P175

[2]

2010 Rheumatoid Arthritis Classification Criteria An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative [J].