Influence of age-related maculopathy on visual functioning and health-related quality of life

被引:192
作者
Mangione, CM
Gutierrez, PR
Lowe, G
Orav, EJ
Seddon, JM
机构
[1] Univ Calif Los Angeles, Sch Med, Dept Med, Div Gen Med & Hlth Serv Res, Los Angeles, CA 90024 USA
[2] Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Dept Ophthalmol,Epidemiol Unit, Boston, MA USA
[3] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Div Gen Med, Boston, MA 02115 USA
[4] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA
关键词
D O I
10.1016/S0002-9394(99)00169-5
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
PURPOSE: To describe the influence of age-related maculopathy on visual functioning and health-related quality of life. METHODS: A prospective, cross-sectional, observational cohort sample of 201 persons with various stages of age-related maculopathy was recruited from the Massachusetts Eye and Ear Infirmary as part of a longitudinal study of age-related macular degeneration, Persons were considered to have age-related maculopathy if one or more of the following clinical characteristics were present: drusen, retinal pigment epithelial changes, geographic atrophy, or evidence of exudative disease. Median corrected visual acuity for this sample was 20/25 in the better eye, with all subjects having 20/200 or better visual acuity in at least one eye at baseline. All participants underwent a comprehensive ophthalmologic examination with a dilated pupil. In addition to the usual clinical data collection, severity of age-related maculopathy was graded by an ophthalmologist who used standard clinical criteria and was masked to the participants' descriptions of visual functioning and health-related quality of life. All participants completed an interview that included the Activities of Daily Vision Scale, a survey designed to assess difficulties with routine daily activities that require vision, and the Short Form-36 Health Survey, a generic measure of multidimensional health-related quality of life, RESULTS: Severity of age-related maculopathy was associated with poorer scores of the Activities of Daily Vision Scale. This association was most significant for near vision and driving activities. In this sample, the SF-36 Health Survey scales were not significantly correlated with severity of age-related maculopathy. CONCLUSIONS: Reported visual functioning is significantly associated with the clinical severity of age-related maculopathy. However, once visual acuity is taken into consideration, clinical grading of age-related maculopathy did not explain a significant portion of the variation in visual functioning. The lack of significant correlation between severity of age-related maculopathy and the SF-36 Health Survey may have resulted from the small number of participants in our sample with severe bilateral age-related maculopathy. (Am J Ophthalmol 1999; 128:4-5-53. (C) 1999 by Elsevier Science Inc. All rights reserved.)
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页码:45 / 53
页数:9
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