Leptin and its receptors in human fetal and adult ovaries

被引:19
作者
Abir, R
Ao, A
Jin, SG
Barnett, M
Raanani, H
Ben-Haroush, A
Fisch, B
机构
[1] Rabin Med Ctr, Dept Obstet & Gynecol, Infertil & IVF Unit, IL-49100 Petah Tiqwa, Israel
[2] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
[3] McGill Univ, Royal Victoria Hosp, Dept Obstet & Gynecol, Montreal, PQ H3A 2T5, Canada
[4] McGill Univ, Dept Human Genet, Montreal, PQ, Canada
关键词
D O I
10.1016/j.fertnstert.2005.05.067
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The objective of the study was to investigate the immunocytochemical expression and presence of messenger RNA (mRNA) transcripts for leptin and its receptors in ovaries from human adults and adolescents and second- and third-trimester fetuses. Staining for leptin and the long form of its receptor was identified in oocytes of follicles from primordial stages onward, and for leptin only in granulosa cells of a minority of the samples. Expression of mRNA transcripts for both ligands was detected in all the samples tested.
引用
收藏
页码:1779 / 1782
页数:4
相关论文
共 26 条
[1]   Presence of NGF and its receptors in ovaries from human fetuses and adults [J].
Abir, R ;
Fisch, B ;
Jin, S ;
Barnnet, M ;
Ben-Haroush, A ;
Felz, C ;
Kessler-Icekson, G ;
Feldberg, D ;
Nitke, S ;
Ao, A .
MOLECULAR HUMAN REPRODUCTION, 2005, 11 (04) :229-236
[2]   Immunocytochemical detection and RT-PCR expression of leukaemia inhibitory factor and its receptor in human fetal and adult ovaries [J].
Abir, R ;
Fisch, B ;
Jin, S ;
Barnet, M ;
Freimann, S ;
Van den Hurk, R ;
Feldberg, D ;
Nitke, S ;
Krissi, H ;
Ao, A .
MOLECULAR HUMAN REPRODUCTION, 2004, 10 (05) :313-319
[3]   Leptin attenuates follicular apoptosis and accelerates the onset of puberty in immature rats [J].
Almog, B ;
Gold, R ;
Tajima, K ;
Dantes, A ;
Salim, K ;
Rubinstein, M ;
Barkan, D ;
Homburg, R ;
Lessing, JB ;
Nevo, N ;
Gertler, A ;
Amsterdam, A .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2001, 183 (1-2) :179-191
[4]   Leptin is a metabolic signal to the reproductive system [J].
Barash, IA ;
Cheung, CC ;
Weigle, DS ;
Ren, HP ;
Kabigting, EB ;
Kuijper, JL ;
Clifton, DK ;
Steiner, RA .
ENDOCRINOLOGY, 1996, 137 (07) :3144-3147
[5]   Leptin induces ovulation in GnRH-deficient mice [J].
Barkan, D ;
Hurgin, V ;
Dekel, N ;
Amsterdam, A ;
Rubinstein, M .
FASEB JOURNAL, 2004, 18 (13) :133-+
[6]  
BATT RAL, 1982, J REPROD FERTIL, V64, P363
[7]   Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin [J].
Chehab, FE ;
Lim, ME ;
Lu, RH .
NATURE GENETICS, 1996, 12 (03) :318-320
[8]   Leptin's actions on the reproductive axis: Perspectives and mechanisms [J].
Cunningham, MJ ;
Clifton, DK ;
Steiner, RA .
BIOLOGY OF REPRODUCTION, 1999, 60 (02) :216-222
[9]   Regulation of ovarian follicular development in primates: Facts and hypotheses [J].
Gougeon, A .
ENDOCRINE REVIEWS, 1996, 17 (02) :121-155
[10]   Folliculogenesis is impaired and granulosa cell apoptosis is increased in leptin-deficient mice [J].
Hamm, ML ;
Bhat, GK ;
Thompson, WE ;
Mann, DR .
BIOLOGY OF REPRODUCTION, 2004, 71 (01) :66-72