Cloning, tissue distribution, subcellular localization and overexpression of murine histidine-rich Ca2+ binding protein

被引：20

作者：

Ridgeway, AG ^{[1
]}

Petropoulos, H ^{[1
]}

Siu, A ^{[1
]}

Ball, JK ^{[1
]}

Skerjanc, IS ^{[1
]}

机构：

[1] Univ Western Ontario, Dept Biochem, London, ON N6A 5C1, Canada

来源：

FEBS LETTERS | 1999年 / 456卷 / 03期

基金：

英国医学研究理事会; 加拿大自然科学与工程研究理事会;

关键词：

sarcoplasmic reticulum; Ca2+ binding; leukemia; striated muscle;

D O I：

10.1016/S0014-5793(99)00993-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The histidine-rich Ca2+ binding protein (HRC) resides in the sarcoplasmic reticulum of muscle and binds Ca2+. Since Ca2+ concentrations can regulate gene expression via calcineurin, the mouse homologue of HRC (mHRC) was isolated and characterized. mHRC was detected in muscle progenitor cells, in primary clonal thymic tumors and a tumor cell line, suggesting a broader role for mHRC than in Ca2+ storage during muscle contraction. mHRC was present in the perinuclear region of myoblasts, To examine if it can regulate gene expression, mHRC was overexpressed in cells differentiating into cardiac and skeletal muscle, mHRC had no effect on cardiogenesis or myogenesis. Therefore, if mHRC plays a role in the regulation of gene expression during cellular differentiation, it does not appear to be either rate-limiting or inhibitory. (C) 1999 Federation of European Biochemical Societies.

引用

页码：399 / 402

页数：4

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