Theophylline release from poly(acrylic acid-co-acrylamide) hydrogels

被引：47

作者：

Katime, I

Novoa, R

de Apodaca, ED

Mendizábal, E

Puig, J

机构：

[1] Univ Basque Country, Fac Ciencias, Dept Quim Fis, Grupo Neuvos Mat, E-48080 Bilbao, Spain

[2] Univ Guadalajara, Fac Ciencias Quim, Guadalajara 44430, Jalisco, Mexico

来源：

POLYMER TESTING | 1999年 / 18卷 / 07期

关键词：

D O I：

10.1016/S0142-9418(98)00054-3

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Hydrogels are hydrophilic polymers that swell to an equilibrium volume in the presence of water but preserve their shape. The dynamic swelling behavior of poly(acrylic acid-co-acrylamide) copolymers, at 37 degrees C, was investigated. It was observed that the liberation mechanism was non-Fickian, Diffusion coefficients according to Ficks law as a function of concentration of N,N'-methylenebisacrylamide and results on the effects of crosslink density on the release of theophylline are reported. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：559 / 566

页数：8

相关论文

共 14 条

[1] ASPECTS OF 3 TYPES OF HYDROGELS FOR BIOMEDICAL APPLICATIONS [J].

BRUCK, SD .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1973, 7 (05) :387-404

[2] SWELLING-CONTROLLED, CONSTANT RATE DELIVERY SYSTEMS [J].

HOPFENBERG, HB ;

HSU, KC .

POLYMER ENGINEERING AND SCIENCE, 1978, 18 (15) :1186-1191

[3] FACTORS AFFECTING WATER SORPTION IN AND SOLUTE RELEASE FROM GLASSY ETHYLENE-VINYL ALCOHOL CO-POLYMERS [J].

HOPFENBERG, HB ;

APICELLA, A ;

SALEEBY, DE .

JOURNAL OF MEMBRANE SCIENCE, 1981, 8 (03) :273-282

[4]

HUGLIN MB, 1983, ANGEW MAKROMOL CHEM, V118, P197, DOI 10.1002/apmc.1983.051180115

[5] MECHANISMS OF SOLUTE RELEASE FROM POROUS HYDROPHILIC POLYMERS [J].

KORSMEYER, RW ;

GURNY, R ;

DOELKER, E ;

BURI, P ;

PEPPAS, NA .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1983, 15 (01) :25-35

[6]

Korsmeyer RW., 1984, J Cont Rel, V1, P89, DOI [10.1016/0168-3659(84)90001-4, DOI 10.1016/0168-3659(84)90001-4]

[7]

LEE PI, 1983, POLYM COMMUN, V24, P45

[8] NOVEL-APPROACH TO ZERO-ORDER DRUG DELIVERY VIA IMMOBILIZED NONUNIFORM DRUG DISTRIBUTION IN GLASSY HYDROGELS [J].

LEE, PI .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1984, 73 (10) :1344-1347

[9] THE SWELLING INTERFACE NUMBER AS A CRITERION FOR PREDICTION OF DIFFUSIONAL SOLUTE RELEASE MECHANISMS IN SWELLABLE POLYMERS [J].

PEPPAS, NA ;

FRANSON, NM .

JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS, 1983, 21 (06) :983-997

[10] AN INVITRO ASSESSMENT OF WOUND DRESSING CONFORMABILITY [J].

QUEEN, D ;

EVANS, JH ;

GAYLOR, JDS ;

COURTNEY, JM ;

REID, WH .

BIOMATERIALS, 1987, 8 (05) :372-376