Dissecting Hirschsprung disease

被引：41

作者：

Passarge, E ^{[1
]}

机构：

[1] Univ Essen Gesamthsch Klinikum, Inst Humangenet, D-45122 Essen, Germany

来源：

NATURE GENETICS | 2002年 / 31卷 / 01期

关键词：

D O I：

10.1038/ng878

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Nonsyndromic Hirschsprung disease, hitherto assumed to be a multifactorial disease with a threshold effect due to an unknown number of genes, has been genetically dissected and shown to result from an interaction between just three loci, two of which have not previously been associated with the disease. Oligogenic inheritance can explain the main aspects of its genetic

引用

页码：11 / 12

页数：2

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