A 12-Week Physical and Cognitive Exercise Program Can Improve Cognitive Function and Neural Efficiency in Community-Dwelling Older Adults: A Randomized Controlled Trial

被引：142

作者：

Nishiguchi, Shu ^{[1
,2
]}

Yamada, Minoru ^{[3
]}

Tanigawa, Takanori ^{[1
]}

Sekiyama, Kaoru ^{[4
]}

Kawagoe, Toshikazu ^{[2
,4
]}

Suzuki, Maki ^{[4
]}

Yoshikawa, Sakiko ^{[5
]}

Abe, Nobuhito ^{[5
]}

Otsuka, Yuki ^{[5
]}

Nakai, Ryusuke ^{[5
]}

Aoyama, Tomoki ^{[1
]}

Tsuboyama, Tadao ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Human Hlth Sci, Dept Phys Therapy, Kyoto, Japan

[2] Japan Soc Promot Sci, Tokyo, Japan

[3] Univ Tsukuba, Grad Sch Comprehens Human Sci, Tokyo 1120012, Japan

[4] Kumamoto Univ, Grad Sch Social & Cultural Sci, Kumamoto, Japan

[5] Kyoto Univ, Kokoro Res Ctr, Kyoto, Japan

来源：

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY | 2015年 / 63卷 / 07期

基金：

日本学术振兴会;

关键词：

cognitive improvement; physical and cognitive exercise program; fMRI; randomized controlled trial; WORKING-MEMORY; ALZHEIMERS-DISEASE; STEPPING EXERCISE; DEMENTIA; RISK; PERFORMANCE; IMPAIRMENT; TASK; COMPENSATION; INTERVENTION;

D O I：

10.1111/jgs.13481

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

ObjectivesTo investigate whether a 12-week physical and cognitive exercise program can improve cognitive function and brain activation efficiency in community-dwelling older adults. DesignRandomized controlled trial. SettingKyoto, Japan. ParticipantsCommunity-dwelling older adults (N=48) were randomized into an exercise group (n=24) and a control group (n=24). InterventionExercise group participants received a weekly dual task-based multimodal exercise class in combination with pedometer-based daily walking exercise during the 12-week intervention phase. Control group participants did not receive any intervention and were instructed to spend their time as usual during the intervention phase. MeasurementsThe outcome measures were global cognitive function, memory function, executive function, and brain activation (measured using functional magnetic resonance imaging) associated with visual short-term memory. ResultsExercise group participants had significantly greater postintervention improvement in memory and executive functions than the control group (P<.05). In addition, after the intervention, less activation was found in several brain regions associated with visual short-term memory, including the prefrontal cortex, in the exercise group (P<.001, uncorrected). ConclusionA 12-week physical and cognitive exercise program can improve the efficiency of brain activation during cognitive tasks in older adults, which is associated with improvements in memory and executive function.

引用

页码：1355 / 1363

页数：9

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