Mesenchymal stromal cells: a key player in innate tolerance'?

被引：65

作者：

Dazzi, Francesco ^{[1
]}

Lopes, Luciene ^{[1
]}

Weng, Ling ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Med, London W12 0NN, England

来源：

IMMUNOLOGY | 2012年 / 137卷 / 03期

基金：

英国医学研究理事会;

关键词：

immunosuppression; immune regulation; mesenchymal stem cells; tolerance; VERSUS-HOST-DISEASE; HEMATOPOIETIC STEM-CELLS; REGULATORY T-CELLS; IN-VITRO; INTERNATIONAL-SOCIETY; INTERFERON-GAMMA; IFN-GAMMA; NK CELLS; INHIBIT; DIFFERENTIATION;

D O I：

10.1111/j.1365-2567.2012.03621.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The existence of a mesenchymal stromal cell (MSC) population with the main property of physically supporting parenchymal tissues has long been recognized in virtually all organs. However, it was only recently that MSC have been identified as playing a novel role in modulating inflammation. It has been extensively documented that, under particular circumstances, MSC potently impair virtually all cells of the immune system, including antigen-presenting-cells.

引用

页码：206 / 213

页数：8

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