The NOD mouse model of type 1 diabetes: As good as it gets?

被引：471

作者：

Atkinson, MA ^{[1
]}

Leiter, EH

机构：

[1] Univ Florida, Coll Med, Dept Pathol, Gainesville, FL 32610 USA

[2] Jackson Lab, Bar Harbor, ME 04609 USA

来源：

NATURE MEDICINE | 1999年 / 5卷 / 06期

关键词：

D O I：

10.1038/9442

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Of the two well-known rodent models of human type 1 diabetes (the non-obese diabetic mouse and the BioBreeding rat) the mouse has become the model of choice. Here the authors re-examine the value of this mouse model as a tool for understanding human diabetes and for testing potential therapies, reviewing both strengths and weaknesses.

引用

页码：601 / 604

页数：4

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