Lysophospholipids - Receptor revelations

被引：453

作者：

Hla, T ^{[1
]}

Lee, MJ ^{[1
]}

Ancellin, N ^{[1
]}

Paik, JH ^{[1
]}

Kluk, MJ ^{[1
]}

机构：

[1] Univ Connecticut, Ctr Vasc Biol, Dept Physiol, Farmington, CT 06030 USA

来源：

SCIENCE | 2001年 / 294卷 / 5548期

关键词：

D O I：

10.1126/science.1065323

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Upon cell activation, membrane phospholipids are metabolized into potent lysophospholipid (LP) mediators, such as sphingosine 1-phosphate and lysophosphatidic acid. LPs fulfill signaling roles in organisms as diverse as yeast and humans. The recent discovery of G protein-coupled receptors for LPs in higher eukaryotes, and their involvement in regulating diverse processes such as angiogenesis, cardiac development, neuronal survival, and immunity, has stimulated growing interest in these Lipid mediators. LP receptor biology has generated insights into fundamental cellular mechanisms and may provide therapeutic targets for drug development.

引用

页码：1875 / 1878

页数：4

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