Intranasal and subcutaneous immunization under the effect of estradiol leads to better protection against genital HSV-2 challenge compared to progesterone

被引：38

作者：

Bhavanam, Sudha ^{[1
]}

Snider, Denis R. ^{[2
]}

Kaushic, Charu ^{[1
]}

机构：

[1] McMaster Univ, Michael G DeGroote Ctr Learning & Discovery, Ctr Gene Therapeut, Dept Pathol & Mol Med, Hamilton, ON, Canada

[2] McMaster Univ, Intestinal Dis Res Program, Dept Pathol & Mol Med, Hamilton, ON, Canada

来源：

VACCINE | 2008年 / 26卷 / 48期

基金：

加拿大健康研究院;

关键词：

Sex hormone; Immunization; HSV-2; Protection; Estradiol; Immune responses;

D O I：

10.1016/j.vaccine.2008.08.045

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This Study examined the effect of hormonal environment on intranasal and Subcutaneous routes of immunization in a genital herpes infection model. Ovariectomized mice were treated with estradiol (E-2), progesterone (P-4) or placebo hormone pellets and immunized intranasally (i.n.) or subcutaneously (s.c.) with attenuated HSV-2. Immunized mice were subsequently challenged, intravaginally, with wild-type HSV-2. Mice immunized under the influence of E-2 showed higher Survival rates, reduced pathology and significantly lower viral shedding compared with those immunized under the influence Of P4 or placebo, by both i.n. and s.c. routes. Vaginal and serum anti-HSV-2 IgG, but not IgA, levels correlated with decreased E-2-treated, i.n. immunized mice. We conclude that immunization Linder the influence of E-2 afforded better protection compared to placebo and P-4, by both routes of immunization. Female sex hormones can influence immune responses and outcome of viral challenge in the genital tract following systemic immunization. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：6165 / 6172

页数：8

共 31 条

[1] Interactions of the female hormonal environment, susceptibility to viral infections, and disease progression [J].