Regulatory T cells in transplantation

被引：67

作者：

Waldmann, H ^{[1
]}

Chen, TC ^{[1
]}

Graca, L ^{[1
]}

Adams, E ^{[1
]}

Daley, S ^{[1
]}

Cobbold, S ^{[1
]}

Fairchild, PJ ^{[1
]}

机构：

[1] Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

SEMINARS IN IMMUNOLOGY | 2006年 / 18卷 / 02期

基金：

英国医学研究理事会;

关键词：

tolerance; privilege; regulation; infectious tolerance; regulatory T cell;

D O I：

10.1016/j.smim.2006.01.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Our ability to harness tolerance mechanisms will have a major impact in organ transplantation. It should enable drug minimization, and eventually, the elimination of all immunosuppressive drugs. An improved understanding of the biology of regulatory T cells will make it possible to replace current induction regimens with those favouring the selective vaccination of T cells that prevent graft rejection. Once regulation is established, the continued supply of graft antigens should empower T cell regulation to become the dominant natural mechanism to prevent graft rejection. (c) 2006 Elsevier Ltd. All rights reserved.

引用

收藏

页码：111 / 119

页数：9

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