HIV infection and the gastrointestinal immune system

被引：381

作者：

Brenchley, J. M. ^{[1
]}

Douek, D. C. ^{[1
]}

机构：

[1] NIAID, Human Immunol Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

来源：

MUCOSAL IMMUNOLOGY | 2008年 / 1卷 / 01期

关键词：

D O I：

10.1038/mi.2007.1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There has recently been a resurgence of interest in the gastrointestinal pathology observed in patients infected with HIV. The gastrointestinal tract is a major site of HIV replication, which results in massive depletion of lamina propria CD4 T cells during acute infection. Highly active antiretroviral therapy leads to incomplete suppression of viral replication and substantially delayed and only partial restoration of gastrointestinal CD4 T cells. The gastrointestinal pathology associated with HIV infection comprises significant enteropathy with increased levels of inflammation and decreased levels of mucosal repair and regeneration. Assessment of gut mucosal immune system has provided novel directions for therapeutic interventions that modify the consequences of acute HIV infection.

引用

页码：23 / 30

页数：8

共 104 条

[1] PHYSIOLOGICAL-EFFECTS OF HIV-INFECTION ON HUMAN INTESTINAL EPITHELIAL-CELLS - AN IN-VITRO MODEL FOR HIV ENTEROPATHY [J].

ASMUTH, DM ;

HAMMER, SM ;

WANKE, CA .

AIDS, 1994, 8 (02) :205-211

[2] Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria [J].

Ayabe, T ;

Satchell, DP ;

Wilson, CL ;

Parks, WC ;

Selsted, ME ;

Ouellette, AJ .

NATURE IMMUNOLOGY, 2000, 1 (02) :113-118

[3] To the editor: CCR5-specific mucosal IgA in saliva and genital fluids of HIV-exposed seronegative subjects [J].

Barassi, C ;

Lazzarin, A ;

Lopalco, L .

BLOOD, 2004, 104 (07) :2205-2206

[4] ISOLATION OF A T-LYMPHOTROPIC RETROVIRUS FROM A PATIENT AT RISK FOR ACQUIRED IMMUNE-DEFICIENCY SYNDROME (AIDS) [J].

BARRESINOUSSI, F ;

CHERMANN, JC ;

REY, F ;

NUGEYRE, MT ;

CHAMARET, S ;

GRUEST, J ;

DAUGUET, C ;

AXLERBLIN, C ;

VEZINETBRUN, F ;

ROUZIOUX, C ;

ROZENBAUM, W ;

MONTAGNIER, L .

SCIENCE, 1983, 220 (4599) :868-871

[5] JEJUNAL ENTEROPATHY ASSOCIATED WITH HUMAN IMMUNODEFICIENCY VIRUS-INFECTION - QUANTITATIVE HISTOLOGY [J].

BATMAN, PA ;

MILLER, ARO ;

FORSTER, SM ;

HARRIS, JRW ;

PINCHING, AJ ;

GRIFFIN, GE .

JOURNAL OF CLINICAL PATHOLOGY, 1989, 42 (03) :275-281

[6]

BATMAN PA, 1994, AIDS, V8, P161, DOI 10.1097/00002030-199402000-00003

[7] HIV enteropathy: crypt stem and transit cell hyperproliferation induces villous atrophy in HIV/microsporidia-infected jejunal mucosa [J].

Batman, Philip A. ;

Kotler, Donald P. ;

Kapembwa, Moses S. ;

Booth, Dawn ;

Potten, Christopher S. ;

Orenstein, Jan M. ;

Scally, Andrew J. ;

Griffin, George E. .

AIDS, 2007, 21 (04) :433-439

[8] Impact of vaccine-induced mucosal high-avidity CD8+CTLs in delay of AIDS viral dissemination from mucosa [J].

Belyakov, IM ;

Kuznetsov, VA ;

Kelsall, B ;

Klinman, D ;

Moniuszko, M ;

Lemon, M ;

Markham, PD ;

Pal, R ;

Clements, JD ;

Lewis, MG ;

Strober, W ;

Franchini, GA ;

Berzofsky, JA .

BLOOD, 2006, 107 (08) :3258-3264

[9] HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells [J].

Betts, Michael R. ;

Nason, Martha C. ;

West, Sadie M. ;

De Rosa, Stephen C. ;

Migueles, Stephen A. ;

Abraham, Jonathan ;

Lederman, Michael M. ;

Benito, Jose M. ;

Goepfert, Paul A. ;

Connors, Mark ;

Roederer, Mario ;

Koup, Richard A. .

BLOOD, 2006, 107 (12) :4781-4789

[10] Intestinal inflammation, ileal structure and function in HIV [J].

Bjarnason, I ;

Sharpstone, DR ;

Francis, N ;

Marker, A ;

Taylor, C ;

Barrett, M ;

Macpherson, A ;

Baldwin, C ;

Menzies, IS ;

Crane, RC ;

Smith, T ;

Pozniak, A ;

Gazzard, BG .

AIDS, 1996, 10 (12) :1385-1391

← 1 2 3 4 5 6 7 8 9 10 →