Contribution to the biophysics of the lethal effects of electric field on microorganisms

被引：26

作者：

Kekez, MM ^{[1
]}

Savic, P ^{[1
]}

Johnson, BF ^{[1
]}

机构：

[1] CARLETON UNIV,DEPT BIOL,OTTAWA,ON K1S 5B6,CANADA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1996年 / 1278卷 / 01期

关键词：

electrical breakdown; cell electrodynamics; cell membrane; electroporation; electric field; lethal effect;

D O I：

10.1016/0005-2736(95)00194-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The proposed model assumes that the criteria leading to the lethal breakdown of microorganisms suspended in a continuous medium depend on two parameters: (a) the applied electric field must exceed the critical field of membrane to create holes and (b) the Joule energy (deposited in the membrane) must exceed the minimum value beyond which the cell can not recover. The first parameter initiates (reversible) breakdown and the second one, the completion of the (irreversible) electrical breakdown leading to death of the cell. The number of cells surviving the electric field treatment is related to statistical distribution of cell size. Comparison between theory and the experimental results of Kinosita and Tsong (1977); Hulsheger et al. (1980, 1981, 1983); Rosemberg and Korenstein (1990) and others is given.

引用

页码：79 / 88

页数：10

共 21 条

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[2]

Chang D.C., 1992, GUIDE ELECTROPORATIO

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