Enantioselective Friedel-Crafts alkylation of indoles with nitroalkenes catalyzed by bifunctional tridentate bis(oxazoline)-Zn(II) complex

被引：171

作者：

Lu, SF ^{[1
]}

Du, DM ^{[1
]}

Xu, JX ^{[1
]}

机构：

[1] Peking Univ, Coll Chem & Mol Engn, BNLMS, Key Lab Bioorgan Chem & Mol Engn, Beijing 100871, Peoples R China

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 10期

关键词：

D O I：

10.1021/ol060586f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A more practical and efficient catalytic asymmetric Friedel-Crafts alkylation of indoles with nitroalkenes using bifunctional tridentate bis(oxazoline)-Zn(OTf)(2) as catalyst has been developed. Various types of the nitroalkylated indoles were obtained in excellent yields (85-99%) and high enantioselectivities (up to 98% ee).

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页码：2115 / 2118

页数：4

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