Y-chromosomal DNA haplotype differences in control and infertile Italian subpopulations

被引：25

作者：

Previderé, C

Stuppia, L

Gatta, V

Fattorini, P

Palka, G

Tyler-Smith, C

机构：

[1] Univ Oxford, Dept Biochem, CRC, Chromosome Mol Biol Grp, Oxford OX1 3QU, England

[2] Univ G DAnnunzio, Dipartimento Sci Biomed, Sez Genet Med, Chieti, Italy

[3] CNR, Ist Citomorfol Umana Normale & Patol, Chieti, Italy

[4] Ist Med Legale & Assicurazioni, Trieste, Italy

来源：

EUROPEAN JOURNAL OF HUMAN GENETICS | 1999年 / 7卷 / 06期

关键词：

Y-chromosomal DNA haplotype; biallelic marker; SNP; male infertility; population substructure;

D O I：

10.1038/sj.ejhg.5200359

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Y-chromosomal DNA haplotypes were determined in 74 infertile and 216 control Italian males using eight biallelic markers. A significant difference in haplotype frequency was found, but could be explained by the geographical origins of the samples. The Y chromosome is thus a sensitive marker for population substructuring and may be useful for determining whether two population samples come from a single population, for example in association studies.

引用

页码：733 / 736

页数：4

共 20 条

[1] The molecular genetics of male infertility [J].