Why is p53 acetylated?

被引：180

作者：

Prives, C ^{[1
]}

Manley, JL ^{[1
]}

机构：

[1] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

来源：

CELL | 2001年 / 107卷 / 07期

关键词：

D O I：

10.1016/S0092-8674(01)00619-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies suggest that acetylation of the p53 tumor suppressor protein is not important for its DNA binding activity, as was previously thought. We discuss here a number of theories as to how this modification may serve to regulate the protein's functions.

引用

页码：815 / 818

页数：4

共 20 条

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