Long Noncoding RNAs: Cellular Address Codes in Development and Disease

被引：3219

作者：

Batista, Pedro J. ^{[1
,2
]}

Chang, Howard Y. ^{[1
,2
]}

机构：

[1] Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Program Epithelial Biol, Stanford, CA 94305 USA

来源：

CELL | 2013年 / 152卷 / 06期

关键词：

INTERGENIC TRANSCRIPTION; SELECTIVE ELIMINATION; HISTONE MODIFICATION; NUCLEAR-BODIES; MESSENGER-RNAS; X-INACTIVATION; ANTISENSE RNA; GENE; CHROMATIN; GENOME;

D O I：

10.1016/j.cell.2013.02.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

In biology as in real estate, location is a cardinal organizational principle that dictates the accessibility and flow of informational traffic. An essential question in nuclear organization is the nature of the address code-how objects are placed and later searched for and retrieved. Long noncoding RNAs (IncRNAs) have emerged as key components of the address code, allowing protein complexes, genes, and chromosomes to be trafficked to appropriate locations and subject to proper activation and deactivation. IncRNA-based mechanisms control cell fates during development, and their dysregulation underlies some human disorders caused by chromosomal deletions and translocations.

引用

收藏

页码：1298 / 1307

页数：10

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