Current Concepts in Intestinal Peptide Absorption

被引：32

作者：

Fricker, Gert ^{[1
]}

Drewe, Juergen ^{[2
]}

机构：

[1] Univ Heidelberg, Inst Pharmazeut Technol & Biopharm, Heidelberg, Germany

[2] Kantonsspital, Med Univ Poliklin, CH-4031 Basel, Switzerland

来源：

JOURNAL OF PEPTIDE SCIENCE | 1996年 / 2卷 / 04期

关键词：

peptide absorption; dipeptide carrier; brush border membrane; M-cell; Caco-2; cell;

D O I：

10.1002/psc.66

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Today there is considerable interest in oral peptide delivery. However, oral administration of peptides is limited by a low bioavailability and a high variability in plasma levels. A review is given of the literature describing the major barriers in peptide absorption, the basic mechanisms of intestinal peptide transport, the experimental models and the pharmaceutical approaches currently used in the investigation of peptide and protein absorption processes.

引用

页码：195 / U89

页数：19

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