Expression of G1 phase cyclins in human gastric cancer and gastric mucosa of first-degree relatives

被引：20

作者：

Miehlke, S

Yu, J

Ebert, M

Szokodi, D

Vieth, M

Kuhlisch, E

Buchcik, R

Schimmin, W

Wehrmann, U

Malfertheiner, P

Ehninger, G

Bayerdörffer, E

Stolte, M

机构：

[1] Tech Univ Hosp, Dept Med 1, D-01307 Dresden, Germany

[2] Otto Von Guericke Univ, Dept Gastroenterol Hepatol & Infect Dis, Magdeburg, Germany

[3] Klinikum Bayreuth, Inst Pathol, D-95445 Bayreuth, Germany

[4] Tech Univ Hosp, Dept Surg, Dresden, Germany

[5] Tech Univ, Inst Med Stat & Biometry, Dresden, Germany

[6] City Hosp, Dept Gastroenterol, Dresden, Germany

来源：

DIGESTIVE DISEASES AND SCIENCES | 2002年 / 47卷 / 06期

关键词：

Helicobacter pylori; gastritis; gastric cancer; cyclins; intestinal metaplasia;

D O I：

10.1023/A:1015358127751

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The aim of this study was to investigate the expression of D-type cyclins and cyclin E in gastric cancer patients (N = 34), in healthy first-degree relatives of gastric cancer patients (N = 29), and in control subjects (N = 18). Expression of cyclins D1, D2, D3, and E was determined by RT-PCR. Localization of cyclin expression was determined by immunohistochemistry. Expression of cyclins D2, D3, and E was more frequently detected in tumor tissue compared with tumor-free gastric mucosa (P < 0.05) and was associated with the presence of intestinal metaplasia. In contrast, cyclin D1 was frequently expressed in both tumor- and tumor-free tissue. Cyclin D3 expression was more frequently detected in the antrum mucosa of first-degree relatives compared to controls (P < 0.01) and was associated with the presence of Helicobacter pylori. Our data suggest that deregulation of G(1) phase cyclins may play a role in gastric carcinogenesis, and may point to the presence of molecular alterations in individuals at an increased risk for gastric cancer.

引用

页码：1248 / 1256

页数：9

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