The gut microbiota and obesity: from correlation to causality

被引：675

作者：

Zhao, Liping ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China

[2] Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Key Lab Syst Biomed, Minist Educ, Shanghai 200240, Peoples R China

来源：

NATURE REVIEWS MICROBIOLOGY | 2013年 / 11卷 / 09期

关键词：

DIET-INDUCED OBESITY; GERM-FREE RATS; HIGH-FAT; INTESTINAL MICROBIOTA; METABOLIC ENDOTOXEMIA; BACTERIAL COMMUNITY; INSULIN-RESISTANCE; WIDE ASSOCIATION; BREAST-MILK; MOUSE MODEL;

D O I：

10.1038/nrmicro3089

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The gut microbiota has been linked with chronic diseases such as obesity in humans. However, the demonstration of causality between constituents of the microbiota and specific diseases remains an important challenge in the field. In this Opinion article, using Koch's postulates as a conceptual framework, I explore the chain of causation from alterations in the gut microbiota, particularly of the endotoxin-producing members, to the development of obesity in both rodents and humans. I then propose a strategy for identifying the causative agents of obesity in the human microbiota through a combination of microbiome-wide association studies, mechanistic analysis of host responses and the reproduction of diseases in gnotobiotic animals.

引用

页码：639 / 647

页数：9

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