Radical cations of vitamin E

被引:11
作者
Lehtovuori, P [1 ]
Joela, H [1 ]
机构
[1] Univ Jyvaskyla, Dept Chem, FIN-40351 Jyvaskyla, Finland
关键词
D O I
10.1039/b110970g
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Radical cations of vitamin E compounds (alpha-, beta-, gamma- and delta-tocopherols and alpha-, beta-, gamma- and delta-tocotrienols) were for the first time successfully prepared in different solvents. Their unpaired electron distribution was solved by means of EPR and ENDOR spectroscopy and assignment of isotropic hyperfine couplings was performed. The isotropic hyperfine coupling constants calculated theoretically (UB3LYP) were comparable to those studied experimentally. Radical cations were observed to exist as an intermediate product in the formation of the neutral radical. Moreover, loosening the proton from the radical cation of a tocopherol and from a tocotrienol produced the neutral radical, which was detected in the ENDOR spectrum. The potency of the hydroxyl proton of the radical cation for further reactions as a measure of the biological activity of various tocopherol and tocotrienol compound is discussed.
引用
收藏
页码:1928 / 1933
页数:6
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