MicroRNAs and autoimmunity

被引：97

作者：

Ceribelli, Angela ^{[1
]}

Satoh, Minoru ^{[2
,3
]}

Chan, Edward K. L. ^{[1
]}

机构：

[1] Univ Florida, Dept Oral Biol, Gainesville, FL 32610 USA

[2] Univ Florida, Dept Med, Div Rheumatol & Clin Immunol, Gainesville, FL 32610 USA

[3] Univ Florida, Dept Pathol Immunol & Lab Med, Gainesville, FL 32610 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2012年 / 24卷 / 06期

基金：

美国国家卫生研究院;

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; RHEUMATOID-ARTHRITIS PATIENTS; MESSENGER-RNA TRANSLATION; SIGNALING PROTEINS; IMMUNE-RESPONSES; GW/P-BODIES; T-CELLS; EXPRESSION; MIR-146A; CONTRIBUTES;

D O I：

10.1016/j.coi.2012.07.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The role of microRNAs (miRNAs) in the regulation of many physiological and pathological processes has been intensely studied in recent years. Some miRNAs, such as miR-146a and miR-182, play a dominant role in the regulation of the innate and adaptive immune responses, respectively. Many miRNAs are reportedly deregulated in autoimmune diseases, but miR-146a in particular seems to be consistently altered. The overexpression or underexpression of miRNAs can influence specific targets and pathways, leading to autoimmune disease phenotypes, and this is supported also by some in vivo studies. Targeting miRNAs could represent a valid future therapeutic option for autoimmune diseases.

引用

页码：686 / 691

页数：6

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