The expression of truncated MK in human tumors

被引：57

作者：

Kaname, T

Kadomatsu, K

Aridome, K

Yamashita, S

Sakamoto, K

Ogawa, H

Muramatsu, T

Yamamura, K

机构：

[1] KUMAMOTO UNIV,SCH MED,DEPT SURG,KUMAMOTO 862,JAPAN

[2] NAGOYA UNIV,SCH MED,DEPT BIOCHEM,SHOUWA KU,NAGOYA,AICHI 466,JAPAN

[3] KAGOSHIMA UNIV,FAC MED,DEPT SURG,KAGOSHIMA 890,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 219卷 / 01期

关键词：

D O I：

10.1006/bbrc.1996.0214

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Midkine (MK) is a heparin binding growth/differentiation factor different from fibroblast growth factors (FGFs), and is largely composed of two domains which are formed by a folded polypeptide chain interconnected by disulfide bridges. Polymerase chain reaction revealed the presence of a short MK mRNA in 7 among 12 human tumor cells which expressed MK mRNA. All of 4 pancreatic carcinoma cell lines expressed the short species in addition to the full size mRNA. The short mRNA lacked an exon and resulted in the lack of a more N-terminally located domain. The truncated form of MK was found also in sur surgically removed specimens of human tumors, but not in noncancerous tissue. (C) 1996 Academic Press, Inc.

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页码：256 / 260

页数：5

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