'Feeling the pressure': structural insights into a gated mechanosensitive channel

被引：44

作者：

Spencer, RH

Chang, G

Rees, DC

机构：

[1] CALTECH, Howard Hughes Med Inst, Pasadena, CA 91125 USA

[2] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1999年 / 9卷 / 04期

关键词：

D O I：

10.1016/S0959-440X(99)80063-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure determination of the large-conductance mechanosensitive channel (MscL) from Mycobacterium tuberculosis has revealed the architecture of the first full-length, gated pentameric ion channel. This structure provides insights into the elements participating in the conductance and gating mechanisms of these channels.

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页码：448 / 454

页数：7

相关论文

共 45 条

[1] Release of thioredoxin via the mechanosensitive channel MscL during osmotic downshock of Escherichia coli cells [J].

Ajouz, B ;

Berrier, C ;

Garrigues, A ;

Besnard, M ;

Ghazi, E .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (41) :26670-26674

[2] Channel gate! Tension, leak and disclosure [J].

Batiza, AF ;

Rayment, I ;

Kung, C .

STRUCTURE, 1999, 7 (05) :R99-R103

[3]

Blount P, 1999, Methods Enzymol, V294, P458

[4] Towards an understanding of the structural and functional properties of MscL, a mechanosensitive channel in bacteria [J].

Blount, P ;

Sukharev, SI ;

Moe, PC ;

Nagle, SK ;

Kung, C .

BIOLOGY OF THE CELL, 1996, 87 (1-2) :1-8

[5] Membrane topology and multimeric structure of a mechanosensitive channel protein of Escherichia coli [J].

Blount, P ;

Sukharev, SI ;

Moe, PC ;

Schroeder, MJ ;

Guy, HR ;

Kung, C .

EMBO JOURNAL, 1996, 15 (18) :4798-4805

[6] Mutations in a bacterial mechanosensitive channel change the cellular response to osmotic stress [J].

Blount, P ;

Schroeder, MJ ;

Kung, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (51) :32150-32157

[7] Structure of the MscL homolog from Mycobacterium tuberculosis:: A gated mechanosensitive ion channel [J].

Chang, G ;

Spencer, RH ;

Lee, AT ;

Barclay, MT ;

Rees, DC .

SCIENCE, 1998, 282 (5397) :2220-2226

[8] Estimation of the pore size of the large-conductance mechanosensitive ion channel of Escherichia coli [J].

Cruickshank, CC ;

Minchin, RF ;

LeDain, AC ;

Martinac, B .

BIOPHYSICAL JOURNAL, 1997, 73 (04) :1925-1931

[9] The structure of the potassium channel:: Molecular basis of K+ conduction and selectivity [J].

Doyle, DA ;

Cabral, JM ;

Pfuetzner, RA ;

Kuo, AL ;

Gulbis, JM ;

Cohen, SL ;

Chait, BT ;

MacKinnon, R .

SCIENCE, 1998, 280 (5360) :69-77

[10] Purple bacterial antenna complexes [J].

Fyfe, PK ;

Cogdell, RJ .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1996, 6 (04) :467-472

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