The immunologic and genetic basis of psoriasis

被引：167

作者：

Nickoloff, BJ ^{[1
]}

机构：

[1] Loyola Univ, Med Ctr, Dept Pathol, Skin Canc Res Labs,Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA

来源：

ARCHIVES OF DERMATOLOGY | 1999年 / 135卷 / 09期

关键词：

D O I：

10.1001/archderm.135.9.1104

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

In 1991, a comprehensive review was published highlighting the importance of cytokines in the immunopathogenesis of psoriasis. Since then, many advances have been made regarding the critical role for pathogenic T cells as causing this common and enigmatic skin disease. While epidermal keratinocytes are clearly involved as participants in establishment of the appropriate cytokine milieu as presented earlier, more recent data point to T lymphocytes as triggering the chain reaction of cellular and molecular networks that culminate in the formation of a psoriatic plaque. In this review, 3 major topics will be addressed.

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页码：1104 / 1110

页数：7

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