Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma

被引：146

作者：

Bhatt, Aadra P. ^{[1
,2
]}

Jacobs, Sarah R. ^{[1
,2
]}

Freemerman, Alex J. ^{[3
]}

Makowski, Liza ^{[1
,3
]}

Rathmell, Jeffrey C. ^{[4
,5
]}

Dittmer, Dirk P. ^{[1
,2
]}

Damania, Blossom ^{[1
,2
]}

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Gillings Sch Global Publ Hlth, Sch Med, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Microbiol & Immunol, Gillings Sch Global Publ Hlth, Sch Med, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Dept Nutr, Gillings Sch Global Publ Hlth, Sch Med, Chapel Hill, NC 27599 USA

[4] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Sarah W Stedman Nutr & Metab Ctr, Durham, NC 27710 USA

[5] Duke Univ, Med Ctr, Dept Immunol, Sarah W Stedman Nutr & Metab Ctr, Durham, NC 27710 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2012年 / 109卷 / 29期

基金：

美国国家卫生研究院;

关键词：

Kaposi sarcoma-associated herpesvirus; metabolism; SARCOMA-ASSOCIATED HERPESVIRUS; PRIMARY EFFUSION LYMPHOMA; PROTEIN-COUPLED RECEPTOR; KAPOSIS-SARCOMA; CANCER-CELLS; ENDOTHELIAL-CELLS; K1; PROTEIN; T-LYMPHOCYTES; SYNTHASE; METABOLISM;

D O I：

10.1073/pnas.1205995109

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

The metabolic differences between B-NHL and primary human B cells are poorly understood. Among human B-cell non-Hodgkin lymphomas (B-NHL), primary effusion lymphoma (PEL) is a unique subset that is linked to infection with Kaposi's sarcoma-associated herpesvirus (KSHV). We report that the metabolic profiles of primary B cells are significantly different from that of PEL. Compared with primary B cells, both aerobic glycolysis and fatty acid synthesis (FAS) are up-regulated in PEL and other types of nonviral B-NHL. We found that aerobic glycolysis and FAS occur in a PI3K-dependent manner and appear to be interdependent. PEL overexpress the fatty acid synthesizing enzyme, FASN, and both PEL and other B-NHL were much more sensitive to the FAS inhibitor, C75, than primary B cells. Our findings suggest that FASN may be a unique candidate for molecular targeted therapy against PEL and other B-NHL.

引用

页码：11818 / 11823

页数：6

共 35 条

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