Nod-like receptors in the control of intestinal inflammation

被引：103

作者：

Rubino, Stephen J. ^{[2
]}

Selvanantham, Thirumahal ^{[1
]}

Girardin, Stephen E. ^{[2
]}

Philpott, Dana J. ^{[1
]}

机构：

[1] Univ Toronto, Dept Immunol, Toronto, ON M5S 1A8, Canada

[2] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A8, Canada

来源：

CURRENT OPINION IN IMMUNOLOGY | 2012年 / 24卷 / 04期

关键词：

CARD4 INSERTION/DELETION POLYMORPHISM; CROHNS-DISEASE; BOWEL-DISEASE; ULCERATIVE-COLITIS; PROTECTS MICE; HOST-DEFENSE; SUSCEPTIBILITY; ASSOCIATION; RECOGNITION; VARIANTS;

D O I：

10.1016/j.coi.2012.04.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The Nod-like receptor (NLR) family of intracellular pattern recognition molecules plays critical roles in the control of inflammation through the modulation of different signalling pathways, including those dependent on NF-kappa B and caspase-1-mediated cleavage of interleukin (IL)-1 beta and IL-18. A number of NLRs or NLR-associated proteins have been genetically associated with susceptibility to inflammatory bowel disease (IBD), either Crohn's disease or ulcerative colitis. Accordingly, recent studies have examined the role of NLR proteins in chemical-induced or bacteria-induced murine models of colitis. In this review, we will discuss the genetic associations of NLRs with IBD and the research using NLR-deficient mice in different colitis models.

引用

页码：398 / 404

页数：7

共 54 条

[1]

NALP3 forms an IL-lβ-Processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder [J].

Agostini, L ;

Martinon, F ;

Burns, K ;

McDermott, MF ;

Hawkins, PN ;

Tschopp, J .

IMMUNITY, 2004, 20 (03) :319-325

[2]

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer [J].

Allen, Irving C. ;

TeKippe, Erin McElvania ;

Woodford, Rita-Marie T. ;

Uronis, Joshua M. ;

Holl, Eda K. ;

Rogers, Arlin B. ;

Herfarth, Hans H. ;

Jobin, Christian ;

Ting, Jenny P. -Y. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 207 (05) :1045-1056

[3]

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 [J].

Anderson, Carl A. ;

Boucher, Gabrielle ;

Lees, Charlie W. ;

Franke, Andre ;

D'Amato, Mauro ;

Taylor, Kent D. ;

Lee, James C. ;

Goyette, Philippe ;

Imielinski, Marcin ;

Latiano, Anna ;

Lagace, Caroline ;

Scott, Regan ;

Amininejad, Leila ;

Bumpstead, Suzannah ;

Baidoo, Leonard ;

Baldassano, Robert N. ;

Barclay, Murray ;

Bayless, Theodore M. ;

Brand, Stephan ;

Buening, Carsten ;

Colombel, Jean-Frederic ;

Denson, Lee A. ;

De Vos, Martine ;

Dubinsky, Marla ;

Edwards, Cathryn ;

Ellinghaus, David ;

Fehrmann, Rudolf S. N. ;

Floyd, James A. B. ;

Florin, Timothy ;

Franchimont, Denis ;

Franke, Lude ;

Georges, Michel ;

Glas, Juergen ;

Glazer, Nicole L. ;

Guthery, Stephen L. ;

Haritunians, Talin ;

Hayward, Nicholas K. ;

Hugot, Jean-Pierre ;

Jobin, Gilles ;

Laukens, Debby ;

Lawrance, Ian ;

Lemann, Marc ;

Levine, Arie ;

Libioulle, Cecile ;

Louis, Edouard ;

McGovern, Dermot P. ;

Milla, Monica ;

Montgomery, Grant W. ;

Morley, Katherine I. ;

Mowat, Craig .

NATURE GENETICS, 2011, 43 (03) :246-U94

[4]

CARD15/NOD2 Is Required for Peyer's Patches Homeostasis in Mice [J].

Barreau, Frederick ;

Meinzer, Ulrich ;

Chareyre, Fabrice ;

Berrebi, Dominique ;

Niwa-Kawakita, Michiko ;

Dussaillant, Monique ;

Foligne, Benoit ;

Ollendorff, Vincent ;

Heyman, Martine ;

Bonacorsi, Stephane ;

Lesuffleur, Thecla ;

Sterkers, Ghislaine ;

Giovannini, Marco ;

Hugot, Jean-Pierre .

PLOS ONE, 2007, 2 (06)

[5]

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome [J].

Bauer, Christian ;

Duewell, Peter ;

Mayer, Christine ;

Lehr, Hans Anton ;

Fitzgerald, Katherine A. ;

Dauer, Marc ;

Tschopp, Jurg ;

Endres, Stefan ;

Latz, Eicke ;

Schnurr, Max .

GUT, 2010, 59 (09) :1192-1199

[6]

Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum [J].

Biswas, Amlan ;

Liu, Yuen-Joyce ;

Hao, Liming ;

Mizoguchi, Atsushi ;

Salzman, Nita H. ;

Bevins, Charles L. ;

Kobayashi, Koichi S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (33) :14739-14744

[7]

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis [J].

Bouskra, Djahida ;

Brezillon, Christophe ;

Berard, Marion ;

Werts, Catherine ;

Varona, Rosa ;

Boneca, Ivo Gomperts ;

Eberl, Gerard .

NATURE, 2008, 456 (7221) :507-U34

[8]

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella [J].

Broz, Petr ;

Newton, Kim ;

Lamkanfi, Mohamed ;

Mariathasan, Sanjeev ;

Dixit, Vishva M. ;

Monack, Denise M. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 207 (08) :1745-1755

[9]

Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges [J].

Carvalho, F. A. ;

Nalbantoglu, I. ;

Aitken, J. D. ;

Uchiyama, R. ;

Su, Y. ;

Doho, G. H. ;

Vijay-Kumar, M. ;

Gewirtz, A. T. .

MUCOSAL IMMUNOLOGY, 2012, 5 (03) :288-298

[10]

A Functional Role for Nlrp6 in Intestinal Inflammation and Tumorigenesis [J].

Chen, Grace Y. ;

Liu, Maochang ;

Wang, Fuyuan ;

Bertin, John ;

Nunez, Gabriel .

JOURNAL OF IMMUNOLOGY, 2011, 186 (12) :7187-7194

← 1 2 3 4 5 6 →