Spreading Depression Triggers Headache by Activating Neuronal Panx1 Channels

被引：417

作者：

Karatas, Hulya ^{[1
,2
]}

Erdener, Sefik Evren ^{[1
,2
]}

Gursoy-Ozdemir, Yasemin ^{[1
,2
]}

Lule, Sevda ^{[1
]}

Eren-Kocak, Emine ^{[1
,3
]}

Sen, Zumrut Duygu ^{[1
,3
]}

Dalkara, Turgay ^{[1
,2
]}

机构：

[1] Hacettepe Univ, Inst Neurol Sci & Psychiat, TR-06100 Ankara, Turkey

[2] Hacettepe Univ, Dept Neurol, Fac Med, TR-06100 Ankara, Turkey

[3] Hacettepe Univ, Dept Psychiat, Fac Med, TR-06100 Ankara, Turkey

来源：

SCIENCE | 2013年 / 339卷 / 6123期

关键词：

MENINGEAL NOCICEPTORS; CHROMATIN PROTEIN; MIGRAINE AURA; EXPRESSION; HMGB1; MECHANISMS; PAIN; DEGRANULATION; SENSITIZATION; INFLAMMASOME;

D O I：

10.1126/science.1231897

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

The initial phase in the development of a migraine is still poorly understood. Here, we describe a previously unknown signaling pathway between stressed neurons and trigeminal afferents during cortical spreading depression (CSD), the putative cause of migraine aura and headache. CSD caused neuronal Pannexin1 (Panx1) megachannel opening and caspase-1 activation followed by high-mobility group box 1 (HMGB1) release from neurons and nuclear factor kappa B activation in astrocytes. Suppression of this cascade abolished CSD-induced trigeminovascular activation, dural mast cell degranulation, and headache. CSD-induced neuronal megachannel opening may promote sustained activation of trigeminal afferents via parenchymal inflammatory cascades reaching glia limitans. This pathway may function to alarm an organism with headache when neurons are stressed.

引用

页码：1092 / 1095

页数：4

共 29 条

[1]

Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model [J].