Comparison of oral artesunate and dihydroartemisinin antimalarial bioavailabilities in acute falciparum malaria

被引：44

作者：

Newton, PN

van Vugt, M

Teja-Isavadharm, P

Siriyanonda, D

Rasameesoroj, M

Teerapong, P

Ruangveerayuth, R

Slight, T

Nosten, F

Suputtamongkol, Y

Looareesuwan, S

White, NJ

机构：

[1] Mahidol Univ, Fac Trop Med, Bangkok 10400, Thailand

[2] Mahidol Univ, Fac Pharm, Dept Pharmacol, Bangkok 10400, Thailand

[3] Mae Sot Hosp, Mae Sot, Tak, Thailand

[4] Shoklo Malaria Res Uni, Mae Sot, Tak, Thailand

[5] Armed Forces Res Inst Med Sci, Dept Immunol Med, Bangkok 10400, Thailand

[6] Siriraj Hosp, Dept Med, Bangkok, Thailand

[7] John Radcliffe Hosp, Nuffield Dept Clin Med, Oxford OX3 9DU, England

[8] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/AAC.46.4.1125-1127.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Plasma antimalarial activity following oral artesunate or dihydroartemisinin (DHA) treatment was measured by a bioassay in 18 patients with uncomplicated falciparum malaria. The mean antimalarial activity in terms of the bioavailability of DHA relative to that of artesunate did not differ significantly from 1, suggesting that DHA can be formulated to be an acceptable oral alternative to artesunate.

引用

收藏

页码：1125 / 1127

页数：3

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