Fc-γRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection

被引：243

作者：

Ioan-Facsinay, A

de Kimpe, SJ

Hellwig, SMM

van Lent, PL

Hofhuis, FMA

van Ojik, HH

Sedlik, C

da Silveira, SA

Gerber, J

de Jong, YF

Roozendaal, R

Aarden, LA

van den Berg, WB

Saito, T

Mosser, D

Amigorena, S

Izui, S

van Ommen, GJB

van Vugt, M

van de Winkel, JGJ

Verbeek, JS ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Human Genet, NL-2333 AL Leiden, Netherlands

[2] Utrecht Inst Pharmaceut Sci, Dept Pharmacol & Pathophysiol, NL-3584 CA Utrecht, Netherlands

[3] GenMab, NL-3508 AD Utrecht, Netherlands

[4] Univ Nijmegen, Med Ctr St Radboud, Dept Rheumatol, NL-6525 GA Nijmegen, Netherlands

[5] Univ Utrecht, Med Ctr, Dept Immunol, NL-3584 EU Utrecht, Netherlands

[6] Univ Utrecht, Med Ctr, Dept Immunol, Lab Immunotherapy, NL-3584 EA Utrecht, Netherlands

[7] Univ Utrecht, Med Ctr, Dept Internal Med & Oncol, NL-3584 CX Utrecht, Netherlands

[8] Inst Curie, INSERM, U520, Sect Rech, F-75005 Paris, France

[9] Ctr Med Univ Geneva, Dept Pathol, CH-1211 Geneva 4, Switzerland

[10] Univ Maryland, College Pk, MD 20742 USA

[11] CLB, Dept Autoimmune Dis, NL-1066 CX Amsterdam, Netherlands

[12] Chiba Univ, Grad Sch Med, Dept Mol Genet, Chiba 2608670, Japan

来源：

IMMUNITY | 2002年 / 16卷 / 03期

关键词：

D O I：

10.1016/S1074-7613(02)00294-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The high-affinity receptor for IgG, FcgammaRI, shares its capacity to bind IgG2a immune complexes (IgG2a-IC) with the low-affinity receptor FcgammaRIII and complement factors, hampering the definition of its biological role. Moreover, in vivo, FcgammaRI is occupied by monomeric IgG2a, reducing its accessibility to newly formed IgG2a-IC. By using a variety of FcgammaR(-/-) mice, we demonstrate that in the absence of FcgammaRI, the IgG2a-IC-induced cellular processes of phagocytosis, cytokine release, cellular cytotoxicity, and antigen presentation are impaired. FcgammaRI(-/-) mice showed impaired hypersensitivity responses, strongly reduced cartilage destruction in an arthritis model, and impaired protection from a bacterial infection. We conclude that FcgammaRI contributes substantially to a variety of IgG2a-IC-dependent immune functions and immunopathological responses.

引用

页码：391 / 402

页数：12

共 37 条

[1] Spontaneous autoimmune disease in FcγRIIB-deficient mice results from strain-specific epistasis [J].