Preventive effect of lithospermate B from Salvia miltiorhiza on experimental hepatitis induced by carbon tetrachloride or D-galactosamine/lipopolysaccharide

被引：72

作者：

Hase, K ^{[1
]}

Kasimu, R ^{[1
]}

Basnet, P ^{[1
]}

Kadota, S ^{[1
]}

Namba, T ^{[1
]}

机构：

[1] TOYAMA MED & PHARMACEUT UNIV, RES INST WAKAN YAKU TRADIT SINO JAPANESE MED, TOYAMA 93001, JAPAN

来源：

PLANTA MEDICA | 1997年 / 63卷 / 01期

关键词：

lithospermate B; Salvia miltiorhiza; Labiatae; hepatoprotective effect; lipopolysaccharide; carbon tetrachloride;

D O I：

10.1055/s-2006-957596

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The water extract from the root of Salvia miltiorhiza Bunge showed a protective effect on cultured rat hepatocytes against carbon tetrachloride (CCl4)-induced necrosis. A further study was carried out to isolate the active constituent. Activity guided fractionation of the extract and chemical analysis gave us lithospermate B (a salt of lithospermic acid B), a tetramer of caffeic acid. Lithospermate B was also found to have a potent hepatoprotective activity in not only in vitro but also in vivo experimental liver injuries induced by CCl4 or D-galactosamine (D-GalN)/lipopolysaccharide (LPS).

引用

页码：22 / 26

页数：5

共 23 条

[1] TUMOR-NECROSIS-FACTOR-ALPHA MEDIATES LETHAL ACTIVITY OF KILLED GRAM-NEGATIVE AND GRAM-POSITIVE BACTERIA IN D-GALACTOSAMINE-TREATED MICE [J].

FREUDENBERG, MA ;

GALANOS, C .

INFECTION AND IMMUNITY, 1991, 59 (06) :2110-2115

[2]

FUNG KP, 1993, LIFE SCI, V53, pPL189

[3]

Hase K, 1996, PHYTOTHER RES, V10, P387, DOI 10.1002/(SICI)1099-1573(199608)10:5&lt

[4]

387::AID-PTR856&gt

[5]

3.0.CO

[6]

2-V

[7]

Hase K, 1996, BIOL PHARM BULL, V19, P567, DOI 10.1248/bpb.19.567

[8] INVOLVEMENT OF TUMOR-NECROSIS-FACTOR-ALPHA IN DEVELOPMENT OF HEPATIC-INJURY IN GALACTOSAMINE-SENSITIZED MICE [J].

HISHINUMA, I ;

NAGAKAWA, J ;

HIROTA, K ;

MIYAMOTO, K ;

TSUKIDATE, K ;

YAMANAKA, T ;

KATAYAMA, K ;

YAMATSU, I .

HEPATOLOGY, 1990, 12 (05) :1187-1191

[9] COMPARATIVE ANTILIPOPEROXIDANT, ANTINECROTIC AND SCAVENGING PROPERTIES OF TERPENES AND BIFLAVONES FROM GINKGO AND SOME FLAVONOIDS [J].

JOYEUX, M ;

LOBSTEIN, A ;

ANTON, R ;

MORTIER, F .

PLANTA MEDICA, 1995, 61 (02) :126-129

[10] CHANGES IN URIDINE NUCLEOTIDES DURING LIVER PERFUSION WITH D-GALACTOSAMINE [J].

KEPPLER, D ;

FROHLICH, J ;

REUTTER, W ;

WIELAND, O ;

DECKER, K .

FEBS LETTERS, 1969, 4 (04) :278-+

← 1 2 3 →