Serine and glycine metabolism in cancer

被引：988

作者：

Amelio, Ivano ^{[1
]}

Cutruzzola, Francesca ^{[2
]}

Antonov, Alexey ^{[1
]}

Agostini, Massimiliano ^{[1
]}

Melino, Gerry ^{[1
,3
,4
]}

机构：

[1] Univ Leicester, Toxicol Unit, MRC, Leicester LE1 9HN, Leics, England

[2] Univ Roma La Sapienza, Dept Biochem Sci, I-00185 Rome, Italy

[3] Univ Roma Tor Vergata, IDI IRCCS, Biochem Lab, I-00133 Rome, Italy

[4] Univ Roma Tor Vergata, Dept Expt Med & Surg, I-00133 Rome, Italy

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2014年 / 39卷 / 04期

基金：

英国医学研究理事会;

关键词：

cancer metabolism; serine; glycine; one-carbon metabolism; folate; PYRUVATE-KINASE M2; CELL-PROLIFERATION; P53-INDUCIBLE REGULATOR; GLUTAMINE-METABOLISM; GLYCEMIC INDEX; FOLATE; HYDROXYMETHYLTRANSFERASE; MITOCHONDRIAL; PATHWAY; METHYLATION;

D O I：

10.1016/j.tibs.2014.02.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Serine and glycine are biosynthetically linked, and together provide the essential precursors for the synthesis of proteins, nucleic acids, and lipids that are crucial to cancer cell growth. Moreover, serine/glycine biosynthesis also affects cellular antioxidative capacity, thus supporting tumour homeostasis. A crucial contribution of serine/glycine to cellular metabolism is through the glycine cleavage system,-which refuels one-carbon metabolism; a complex cyclic metabolic network based on chemical reactions of folate compounds. The importance of serine/glycine metabolism is further highlighted by genetic and functional evidence indicating that hyperactivation of the serine/glycine biosynthetic pathway drives oncogenesis. Recent developments in our understanding of these pathways provide novel translational opportunities for drug development, dietary intervention, and biomarker identification of human cancers.

引用

页码：191 / 198

页数：8

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