Abuse and dependence liability of benzodiazepine-type drugs:: GABAA receptor modulation and beyond

被引：159

作者：

Licata, Stephanie C. ^{[1
]}

Rowlett, James K. ^{[2
]}

机构：

[1] Harvard Univ, Sch Med, McLean Hosp, Behav Psychopharmacol Res Lab, Belmont, MA 02478 USA

[2] Harvard Univ, Sch Med, New England Primate Res Ctr, Southborough, MA 01772 USA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 2008年 / 90卷 / 01期

关键词：

benzodiazepines; GABA(A) receptor; abuse potential; reinforcing effects; self-administration; tolerance; dependence;

D O I：

10.1016/j.pbb.2008.01.001

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 [法学]; 0303 [社会学]; 030303 [人类学]; 04 [教育学]; 0402 [心理学];

摘要：

Over the past several decades, benzodiazepines and the newer non-benzodiazepines have become the anxiolytic/hypnotics of choice over the more readily abused barbiturates. While all drugs from this class act at the GABA(A) receptor, benzodiazepine-type drugs offer the clear advantage of being safer and better tolerated. However, there is still potential for these drugs to be abused, and significant evidence exists to suggest that this is a growing problem. This review examines the behavioral determinants of the abuse and dependence liability of benzodiazepine-type drugs. Moreover, the pharmacological and putative biochemical basis of the abuse-related behavior is discussed. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：74 / 89

页数：16

共 214 条

[1]

Differential effects of two chronic diazepam treatment regimes on withdrawal anxiety and AMPA receptor characteristics [J].

Allison, C ;

Pratt, JA .

NEUROPSYCHOPHARMACOLOGY, 2006, 31 (03) :602-619

[2]

Diazepam withdrawal-induced anxiety and place aversion in the rat: differential effects of two chronic diazepam treatment regimes [J].

Allison, C ;

Claase, LA ;

Pratt, JA .

BEHAVIOURAL PHARMACOLOGY, 2002, 13 (5-6) :417-425

[3]

PHARMACOLOGICAL PROFILE OF THE IMIDAZOPYRIDINE ZOLPIDEM AT BENZODIAZEPINE RECEPTORS AND ELECTROCORTICOGRAM IN RATS [J].

ARBILLA, S ;

DEPOORTERE, H ;

GEORGE, P ;

LANGER, SZ .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1985, 330 (03) :248-251

[4]

PROTRACTED WITHDRAWAL SYNDROMES FROM BENZODIAZEPINES [J].

ASHTON, H .

JOURNAL OF SUBSTANCE ABUSE TREATMENT, 1991, 8 (1-2) :19-28

[5]

TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for α2-and α3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates [J].

Atack, JR ;

Wafford, KA ;

Tye, SJ ;

Cook, SM ;

Sohal, B ;

Pike, A ;

Sur, C ;

Melillo, D ;

Bristow, L ;

Bromidge, F ;

Ragan, I ;

Kerby, J ;

Street, L ;

Carling, R ;

Castro, JL ;

Whiting, P ;

Dawson, GR ;

McKernan, RM .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2006, 316 (01) :410-422

[6]

Contributions of GABAA receptor subtype selectivity to abuse liability and dependence potential of pharmacological treatments for anxiety and sleep disorders [J].

Ator, NA .

CNS SPECTRUMS, 2005, 10 (01) :31-39

[7]

Principles of drug abuse liability assessment in laboratory animals [J].

Ator, NA ;

Griffiths, RR .

DRUG AND ALCOHOL DEPENDENCE, 2003, 70 (03) :S55-S72

[8]

Zaleplon and triazolam: drug discrimination, plasma levels, and self-administration in baboons [J].

Ator, NA .

DRUG AND ALCOHOL DEPENDENCE, 2000, 61 (01) :55-68

[9]

Zaleplon and triazolam physical dependence assessed across increasing doses under a once-daily dosing regimen in baboons [J].

Ator, NA ;

Weerts, EM ;

Kaminski, BJ ;

Kautz, MA ;

Griffiths, RR .

DRUG AND ALCOHOL DEPENDENCE, 2000, 61 (01) :69-84

[10]

SELF-ADMINISTRATION OF BARBITURATES AND BENZODIAZEPINES - A REVIEW [J].

ATOR, NA ;

GRIFFITHS, RR .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1987, 27 (02) :391-398

← 1 2 3 4 5 6 7 8 9 10 →