Spatial regulation of BMP activity

被引：82

作者：

Ramel, Marie-Christine ^{[1
]}

Hill, Caroline S. ^{[1
]}

机构：

[1] Canc Res UK London Res Inst, Lab Dev Signalling, London WC2A 3LY, England

来源：

FEBS LETTERS | 2012年 / 586卷 / 14期

关键词：

BMP; Gradient; Morphogen; Signalling; Smad; TGF-beta superfamily; BONE MORPHOGENETIC PROTEIN; TGF-BETA; DPP MORPHOGEN; GRADIENT FORMATION; PATTERN-FORMATION; EXTRACELLULAR REGULATION; EMBRYONIC-DEVELOPMENT; FEEDBACK-REGULATION; RECEPTOR COMPLEXES; IV COLLAGENS;

D O I：

10.1016/j.febslet.2012.02.035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The bone morphogenetic protein (BMP) signalling pathway is critical for embryonic development and tissue homeostasis, and impaired BMP signalling has been implicated in multiple diseases. Molecular tools have been developed to visualise BMP activity in vivo and these have allowed a better understanding of the intricate ways in which BMP activity is regulated spatially. In particular, generation and interpretation of BMP activity gradients during development result from the complex interplay between core BMP signalling components and specific regulators. In this essay we discuss the mechanisms by which spatial regulation of BMP activity is achieved and its functional consequences. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1929 / 1941

页数：13

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