Primed for inflammation: enthesis-resident T cells

被引：79

作者：

Lories, Rik J. ^{[1
]}

McInnes, Iain B. ^{[2
]}

机构：

[1] Katholieke Univ Leuven, Dept Dev & Regenerat, Louvain, Belgium

[2] Univ Glasgow, Coll Med Vet Med & Life Sci, Glasgow, Lanark, Scotland

来源：

NATURE MEDICINE | 2012年 / 18卷 / 07期

关键词：

ANKYLOSING-SPONDYLITIS; SPONDYLOARTHRITIS; HLA-B27;

D O I：

10.1038/nm.2854

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The enthesis is the region at the junction between tendon and bone and has been suggested to be a key target in spondyloarthritic diseases. This zone is now shown to contain a unique population of resident T cells, which, when activated by the cytokine interleukin-23 (IL-23), can promote pathogenesis that is characteristic of spondyloarthritis (pages 1069-1076).

引用

页码：1018 / 1019

页数：2

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